2024
Multi-Omics Analysis of Gut Microbiota and Host Transcriptomics Reveal Dysregulated Immune Response and Metabolism in Young Adults with Irritable Bowel Syndrome
Chen J, Zhao T, Li H, Xu W, Maas K, Singh V, Chen M, Dorsey S, Starkweather A, Cong X. Multi-Omics Analysis of Gut Microbiota and Host Transcriptomics Reveal Dysregulated Immune Response and Metabolism in Young Adults with Irritable Bowel Syndrome. International Journal Of Molecular Sciences 2024, 25: 3514. PMID: 38542485, PMCID: PMC10970623, DOI: 10.3390/ijms25063514.Peer-Reviewed Original ResearchConceptsGut microbiotaIrritable bowel syndrome subjectsHost transcriptomeIrritable bowel syndromeMetabolic pathways of gut microbiotaTranscriptome profilingAnalysis of gut microbiotaDysbiosis of gut microbiotaDysregulated immune responseRNA-seq dataHealthy controlsMulti-omics analysisImmune responseImmune system processRNA-seqGene OntologyBowel syndromeIBS participantsMulti-omicsMicrobiotaMetabolic pathwaysPathways of antigen processingPeripheral blood samplesGutStool samples
2023
DIFFERENTIAL PAIN SENSATION AND GUT MICROBIOME BETWEEN YOUNG AND OLDER ADULTS
Chen J, Wang Z, Starkweather A, Chen M, Miao H, Ahn H, Cong X. DIFFERENTIAL PAIN SENSATION AND GUT MICROBIOME BETWEEN YOUNG AND OLDER ADULTS. Innovation In Aging 2023, 7: 800-800. PMCID: PMC10737760, DOI: 10.1093/geroni/igad104.2582.Peer-Reviewed Original ResearchCold pain thresholdHeat pain thresholdCold detection thresholdGut microbiota profilePressure pain thresholdPain thresholdShannon indexMicrobiota profilesChao indexBeta diversity indicesLower cold pain thresholdStool samplesHigher pressure pain thresholdsQuantitative sensory testing dataYoung adultsAbundant taxaPeripheral sensationAge of young adultsGut microbiotaDiversity indexA-diversityPain sensationSpearman correlation analysisPain processingHigher speciesPain sensation and gut microbiota profiles in older adults with heart failure
Chen J, Wang Z, Starkweather A, Chen M, McCauley P, Miao H, Ahn H, Cong X. Pain sensation and gut microbiota profiles in older adults with heart failure. Interdisciplinary Nursing Research 2023, 2: 83-91. PMID: 37645375, PMCID: PMC10461724, DOI: 10.1097/nr9.0000000000000024.Peer-Reviewed Original ResearchSelf-reported painPain sensationHeart failureHealthy controlsHF subjectsBiomarkers of painPain modulationSevere self-reported painStool samplesGut microbiota compositionQuantitative sensory testing profilesConditioned pain modulationQuantitative sensory testingPressure pain thresholdAssociated with painBrief Pain InventorySymptoms of HFImprove pain managementSubjects' mean ageNIH Patient-Reported Outcomes Measurement Information SystemOlder adultsMicrobiota compositionGut microbiotaPatient-Reported Outcomes Measurement Information SystemPain intensityThe Impact of Early Life Experiences and Gut Microbiota on Neurobehavioral Development in Preterm Infants: A Longitudinal Cohort Study
Chen J, Li H, Zhao T, Chen K, Chen M, Sun Z, Xu W, Maas K, Lester B, Cong X. The Impact of Early Life Experiences and Gut Microbiota on Neurobehavioral Development in Preterm Infants: A Longitudinal Cohort Study. Microorganisms 2023, 11: 814. PMID: 36985387, PMCID: PMC10056840, DOI: 10.3390/microorganisms11030814.Peer-Reviewed Original ResearchNeonatal intensive care unitNeonatal neurobehavioral scaleNeonatal intensive care unit hospitalizationOperational taxonomic unitsPreterm infantsPost-menstrual ageNeurobehavioral developmentGut microbiotaNeonatal intensive care unit admissionWeeks of post-menstrual ageFifty-five infantsDaily stool samplesIntensive care unitLongitudinal cohort studyImpact of early life experiencesNeurobehavioral ScalePretermPostnatal dayClinical featuresCohort studyEarly life experiencesStool samplesCare unitNeurobehavioral outcomesInfants
2022
Sex-specific gut microbiome profiles among preterm infants during the neonatal intensive care hospitalization
Chen J, Li H, Maas K, Starkweather A, Chen M, Cong X. Sex-specific gut microbiome profiles among preterm infants during the neonatal intensive care hospitalization. Interdisciplinary Nursing Research 2022, 1: 6-13. PMID: 36590867, PMCID: PMC9766955, DOI: 10.1097/nr9.0000000000000004.Peer-Reviewed Original ResearchGut microbiome profilesNeonatal intensive care unitNeonatal intensive care unit hospitalizationMicrobiome profilesGut microbiotaPreterm infantsStool samplesComposition of gut microbiotaPredicted metabolic functionsPredictive functional profilingNeonatal gut microbiotaBacterial taxonomic compositionGut microbiota compositionAbundance of membranePreterm neonatesGlycan biosynthesisLipopolysaccharide biosynthesisNeonatal intensive care hospitalizationTaxonomic compositionGene regionB-diversityGut microbiomeMicrobiota compositionMale preterm neonatesDiversity index
2021
Sex Differences in Gut Microbial Development of Preterm Infant Twins in Early Life: A Longitudinal Analysis
Chen J, Li H, Hird S, Chen M, Xu W, Maas K, Cong X. Sex Differences in Gut Microbial Development of Preterm Infant Twins in Early Life: A Longitudinal Analysis. Frontiers In Cellular And Infection Microbiology 2021, 11: 671074. PMID: 34458157, PMCID: PMC8387566, DOI: 10.3389/fcimb.2021.671074.Peer-Reviewed Original ResearchConceptsStatistical Analysis of Metagenomic ProfilesNeonatal intensive care unitGut microbiotaGut microbiomeFunction of gut microbiotaCharacteristics of gut microbiotaReconstruction of Unobserved StatesPhylogenetic Investigation of CommunitiesGut microbial developmentGut microbiota patternInfant gut microbiotaGut microbiota compositionGut microbiome diversityInvestigation of CommunitiesInfant gut microbiomePostnatal ageNeurobehavioral developmentMetagenomic functionsMixed-sex groupsPhylogenetic investigationMetagenomic profilesEnvironmental factorsMicrobiota compositionKEGG pathwaysMicrobiome diversityAltered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components
Barandouzi Z, Lee J, Maas K, Starkweather A, Cong X. Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components. Journal Of Personalized Medicine 2021, 11: 35. PMID: 33429936, PMCID: PMC7827153, DOI: 10.3390/jpm11010035.Peer-Reviewed Original ResearchAlpha diversity indicesGut microbiotaIrritable bowel syndromeDiversity indexHealthy controlsHighest alpha-diversity indicesAlterations of gut microbiota compositionGut microbiota patternHigher alpha diversityGut microbiota compositionGut microbiota alterationsAltered gut microbiotaGut microbiome patternsCaffeine consumptionBowel syndromePathophysiology of irritable bowel syndromeIllumina sequencingFood frequency questionnaireAlpha diversityIrritable bowel syndrome groupIrritable bowel syndrome patientsMicrobial diversityMicrobiota compositionMicrobiota alterationsMicrobiota patterns
2020
Altered Composition of Gut Microbiota in Depression: A Systematic Review
Barandouzi Z, Starkweather A, Henderson W, Gyamfi A, Cong X. Altered Composition of Gut Microbiota in Depression: A Systematic Review. Frontiers In Psychiatry 2020, 11: 541. PMID: 32587537, PMCID: PMC7299157, DOI: 10.3389/fpsyt.2020.00541.Peer-Reviewed Original ResearchGut microbiota patternMicrobiota patternsComposition of gut microbiotaLow abundanceClostridium IV</i>Clostridium XlVa</i>Gut microbiome patternsBrain-gut-microbiome axisGenus levelGut microbiotaB-diversityGut microbiomePhylum levelA-diversityMicrobiome patternsGastrointestinal microbiomeFamily levelMicrobiome findingsMicrobiotaAltered compositionAbundanceGutHealthy controlsMicrobiomeDepressive disorder
2017
Systematic Review of the Effect of Enteral Feeding on Gut Microbiota in Preterm Infants
Xu W, Judge M, Maas K, Hussain N, McGrath J, Henderson W, Cong X. Systematic Review of the Effect of Enteral Feeding on Gut Microbiota in Preterm Infants. Journal Of Obstetric Gynecologic & Neonatal Nursing 2017, 47: 451-463. PMID: 29040820, PMCID: PMC5899689, DOI: 10.1016/j.jogn.2017.08.009.Peer-Reviewed Original ResearchConceptsPreterm infantsGut microbial communityEnteral feedingGut microbiotaEffects of enteral feedingGut microbiomeMicrobial communitiesBreast milk feedingInfant feeding typeMother's own milkGut microbial community structureInfant gut microbial communityDiversity of gut microbiotaSystematic reviewDonor human milkCochrane Database of Systematic ReviewsGut microbiome patternsDatabase of Systematic ReviewsELBW infantsPremature infantsMicrobial community structureSupplementation of prebioticsPretermEffects of probioticsFormula feeding
2016
Gut Microbiome and Infant Health: Brain-Gut-Microbiota Axis and Host Genetic Factors.
Cong X, Xu W, Romisher R, Poveda S, Forte S, Starkweather A, Henderson W. Gut Microbiome and Infant Health: Brain-Gut-Microbiota Axis and Host Genetic Factors. The Yale Journal Of Biology And Medicine 2016, 89: 299-308. PMID: 27698614, PMCID: PMC5045139.Peer-Reviewed Original ResearchConceptsGut microbiomeNeonatal intensive care unitDysbiosis of gut microbiotaSignaling systemHost-microbial interactionsNeonatal gut microbiomeGut microbiotaEvolutionary trajectoriesHigh-risk preterm infantsHost geneticsDysbiosis patternsLong-term infant healthIntensive care unitMicrobiomePreterm infantsEarly life stressGeneticsHuman newbornsRegulation of healthCare unitNeurodevelopmental processesInfant healthHostMedication useDelivery modeGut Microbiome Developmental Patterns in Early Life of Preterm Infants: Impacts of Feeding and Gender
Cong X, Xu W, Janton S, Henderson W, Matson A, McGrath J, Maas K, Graf J. Gut Microbiome Developmental Patterns in Early Life of Preterm Infants: Impacts of Feeding and Gender. PLOS ONE 2016, 11: e0152751. PMID: 27111847, PMCID: PMC4844123, DOI: 10.1371/journal.pone.0152751.Peer-Reviewed Original ResearchConceptsOperational taxonomic unitsGut microbiomeA-diversityGut microbiotaNeonatal intensive care unitPreterm infantsPatterns of gut microbiomeDiversity of gut microbiomeRRNA gene regionInfant gut microbiomeFeeding typeAbundance of EnterobacterialesGut microbiome patternsTaxonomic unitsAbundant phylumGene regionTotal readsAlpha diversityQIIME softwareV4 regionBacterial compositionDevelopmental patternsEarly lifeInfant's postnatal ageMicrobiome patterns