2021
Chronic cannabis smoking-enriched oral pathobiont drives behavioral changes, macrophage infiltration, and increases β-amyloid protein production in the brain
Luo Z, Fitting S, Robinson C, Benitez A, Li M, Wu Y, Fu X, Amato D, Ning W, Funderburg N, Wang X, Zhou Z, Yu X, Wagner A, Cong X, Xu W, Maas K, Wolf B, Huang L, Yu J, Scott A, Mcrae-Clark A, Hamlett E, Jiang W. Chronic cannabis smoking-enriched oral pathobiont drives behavioral changes, macrophage infiltration, and increases β-amyloid protein production in the brain. EBioMedicine 2021, 74: 103701. PMID: 34826801, PMCID: PMC8626580, DOI: 10.1016/j.ebiom.2021.103701.Peer-Reviewed Original ResearchConceptsCannabis smokersActinomyces meyeriCannabis smokingCentral nervous systemOral pathobiontsChronic cannabis smokersMacrophage infiltrationCannabis use disorderOral microbiomeOral microbial dysbiosisSaliva microbiomeNon-smoking controlsIncreased macrophage infiltrationCannabis exposureUse disorderMicrobial 16S rRNA sequencingCannabisCNS abnormalitiesProtein productionActinomyces odontolyticusOral bacteriaBehavioral changesNon-smokersMicrobial dysbiosisNervous system
2015
Early Life Experience and Gut Microbiome
Cong X, Henderson W, Graf J, McGrath J. Early Life Experience and Gut Microbiome. Advances In Neonatal Care 2015, 15: 314-323. PMID: 26240939, PMCID: PMC4583334, DOI: 10.1097/anc.0000000000000191.Peer-Reviewed Original ResearchConceptsGut microbiomeHigh-risk infantsStressful early life experiencesCentral nervous systemSignaling systemPreterm infantsIntestinal innate immunityPain responseBrain-gut-microbiota axisNeonatal careEarly life experiencesNeuroimmune systemMicrobial speciesNervous systemInnate immunityRegulation mechanismInfantsGutMicrobiomeTargeted interventionsRegulationModulating stressPretermState-of-the-science reviewComplex mechanisms