Featured Publications
Distinct neural networks predict cocaine versus cannabis treatment outcomes
Lichenstein S, Kohler R, Ye F, Potenza M, Kiluk B, Yip S. Distinct neural networks predict cocaine versus cannabis treatment outcomes. Molecular Psychiatry 2023, 28: 3365-3372. PMID: 37308679, PMCID: PMC10713861, DOI: 10.1038/s41380-023-02120-0.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingCognitive behavior therapyCognitive behavioral therapySubstance use disordersCannabis abstinenceNeural mechanismsBehavior therapyDistinct neural networksComputer-based trainingCannabis use disorderFMRI scanningNeural predictorsStudy 1Study 2Treatment outcomesContingency managementPrior workComparison subjectsNetwork strengthUse disordersNovel treatment targetsAbstinenceIndependent samplesCocaine abstinenceTreatment responders
2024
Prediction of craving across studies: A commentary on conceptual and methodological considerations when using data-driven methods
Antons S, Yip S, Lacadie C, Dadashkarimi J, Scheinost D, Brand M, Potenza M. Prediction of craving across studies: A commentary on conceptual and methodological considerations when using data-driven methods. Journal Of Behavioral Addictions 2024, 13: 695-701. PMID: 39356557, PMCID: PMC11457034, DOI: 10.1556/2006.2024.00050.Peer-Reviewed Original ResearchConceptsAddictive behaviorsDisorders due to addictive behaviorsConnectome-based predictive modelingPrediction of cravingInvestigate neural mechanismsSubstance use disordersNeural mechanismsCravingSubstance useMethodological considerationsDisordersMethodological featuresBehaviorConceptualizationCommentaryStudyFindingsSubstancesA shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D2/3 receptor densities
Ricard J, Labache L, Segal A, Dhamala E, Cocuzza C, Jones G, Yip S, Chopra S, Holmes A. A shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D2/3 receptor densities. Communications Biology 2024, 7: 1178. PMID: 39300138, PMCID: PMC11413242, DOI: 10.1038/s42003-024-06836-9.Peer-Reviewed Original ResearchConceptsCocaine use disorderPatterns of functional connectivityUse disorderFunctional connectivityReceptor densityLarge-scale functional brain networksMaintenance of substance useDopamine D2/3 receptorsDopamine receptor densityCortico-striatal circuitsProfile of functional connectivitySubstance use disordersFunctional brain networksNeurotransmitter receptor densityD2/3 receptorsDopamine systemTransporter bindingSubcortical systemsBrain networksSubstance useCocaineSpatial topographyDisordersDopamineBiological mechanisms
2020
Is monetary reward processing altered in drug-naïve youth with a behavioral addiction? Findings from internet gaming disorder
Yao YW, Liu L, Worhunsky PD, Lichenstein S, Ma SS, Zhu L, Shi XH, Yang S, Zhang JT, Yip SW. Is monetary reward processing altered in drug-naïve youth with a behavioral addiction? Findings from internet gaming disorder. NeuroImage Clinical 2020, 26: 102202. PMID: 32045732, PMCID: PMC7013339, DOI: 10.1016/j.nicl.2020.102202.Peer-Reviewed Original ResearchConceptsMonetary reward processingInternet gaming disorderReward processingBehavioral addictionsSubstance use disordersNeural responsesGaming disorderMonetary incentive delay taskCurrent fMRI studyDrug-naïve young adultsNon-drug rewardsAltered reward processingIncentive delay taskDrug-naïve youthUse disordersDelay taskProcessing alterationsCaudate activityFMRI studyDrugs of abuseTrait featuresNeural activityNeural featuresOutcome stageSubstance exposure
2017
Is Neural Processing of Negative Stimuli Altered in Addiction Independent of Drug Effects? Findings From Drug-Naïve Youth with Internet Gaming Disorder
Yip SW, Gross JJ, Chawla M, Ma SS, Shi XH, Liu L, Yao YW, Zhu L, Worhunsky PD, Zhang J. Is Neural Processing of Negative Stimuli Altered in Addiction Independent of Drug Effects? Findings From Drug-Naïve Youth with Internet Gaming Disorder. Neuropsychopharmacology 2017, 43: 1364-1372. PMID: 29154365, PMCID: PMC5916358, DOI: 10.1038/npp.2017.283.Peer-Reviewed Original ResearchConceptsDrug-naïve youthNeural processingEmotion regulationNegative affectGaming disorderGroup differencesEmotion regulation taskNegative affective cuesNegative affective stimuliLateral prefrontal cortexInternet gaming disorderAffective cuesAffective stimuliNegative stimuliFMRI scanningIndependent component analysisTask performanceMixed-effects ANOVASubstance use disordersNeural responsesRegulation taskAddictive behaviorsBehavioral addictionsPrefrontal cortexDrugs of abuse
2014
Prenatal Cocaine Exposure and Adolescent Neural Responses to Appetitive and Stressful Stimuli
Yip SW, Potenza EB, Balodis IM, Lacadie CM, Sinha R, Mayes LC, Potenza MN. Prenatal Cocaine Exposure and Adolescent Neural Responses to Appetitive and Stressful Stimuli. Neuropsychopharmacology 2014, 39: 2824-2834. PMID: 24903650, PMCID: PMC4200493, DOI: 10.1038/npp.2014.133.Peer-Reviewed Original ResearchConceptsPrenatal cocaine exposureFavorite-food cuesFunctional magnetic resonance imagingPCE adolescentsPrefrontal cortexVentral striatumNeural responsesBrain regionsAdolescents' neural responsesSubjective food cravingsDorsolateral PFC activationSubjective anxiety ratingsDorsolateral prefrontal cortexCocaine exposureSubcortical brain regionsDevelopment of addictionPFC activationEmotional regulationHuman adolescentsSubstance use disordersAppetitive processingMotivational controlAddiction vulnerabilityHippocampus activityFood cravings