2023
Identification of a Composite Latent Dimension of Reward and Impulsivity Across Clinical, Behavioral, and Neurobiological Domains Among Youth
Kohler R, Lichenstein S, Cheng A, Holmes A, Bzdok D, Pearlson G, Yip S. Identification of a Composite Latent Dimension of Reward and Impulsivity Across Clinical, Behavioral, and Neurobiological Domains Among Youth. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 407-416. PMID: 38052266, PMCID: PMC11149944, DOI: 10.1016/j.bpsc.2023.11.008.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderDisruptive behavior disordersAnterior cingulate responsesLatent dimensionsAnticipatory reward processingDeficit hyperactivity disorderSingle latent dimensionRisk-taking behaviorNegative urgencyExecutive functionIndividual differencesNeurobiological domainsReward anticipationCingulate responseReward processingAdolescent brainCognitive developmentNeural substratesHyperactivity disorderDevelopmental trajectoriesEarly adolescenceMultivariate patternsReward processesBehavioral variablesBehavior disorder
2017
White-matter crossing-fiber microstructure in adolescents prenatally exposed to cocaine
Morie KP, Yip SW, Zhai ZW, Xu J, Hamilton KR, Sinha R, Mayes LC, Potenza MN. White-matter crossing-fiber microstructure in adolescents prenatally exposed to cocaine. Drug And Alcohol Dependence 2017, 174: 23-29. PMID: 28292689, PMCID: PMC5555052, DOI: 10.1016/j.drugalcdep.2017.01.011.Peer-Reviewed Original ResearchConceptsPrenatal cocaine exposureSuperior longitudinal fasciculusPCE adolescentsCrossing-fiber modelsGroup differencesWhole-brain investigationNon-exposed youthWhole-brain analysisSignificant group differencesAltered white matter developmentLeft superior longitudinal fasciculusRisk-taking behaviorNeurobiological underpinningsWhite matter developmentWhite matter microstructureSubstance useWhite matter differencesWhite matter regionsAdolescentsDiffusion-weighted imaging dataCocaine exposureLongitudinal cohortBilateral cingulumCorpus callosumROI analysis