2016
Anticipatory reward processing among cocaine-dependent individuals with and without concurrent methadone-maintenance treatment: Relationship to treatment response
Yip SW, DeVito EE, Kober H, Worhunsky PD, Carroll KM, Potenza MN. Anticipatory reward processing among cocaine-dependent individuals with and without concurrent methadone-maintenance treatment: Relationship to treatment response. Drug And Alcohol Dependence 2016, 166: 134-142. PMID: 27430401, PMCID: PMC5082418, DOI: 10.1016/j.drugalcdep.2016.07.006.Peer-Reviewed Original ResearchConceptsMethadone maintenance treatmentCocaine-dependent individualsBOLD responseCocaine dependenceSignificant public health problemMethadone-maintained individualsMethadone-maintained populationsMethadone-maintained patientsElevated relapse ratesPublic health problemCocaine-negative urinesCocaine-dependent patientsAnticipatory reward processingPosterior cingulate cortexLoss processingDuration of abstinenceDorsolateral prefrontal cortexCD patientsRelapse rateWhole-brain ANOVAInferior frontal gyrusTreatment outcomesRight caudateHealthy comparison participantsPatients
2013
Cortical glutathione levels in young people with bipolar disorder: a pilot study using magnetic resonance spectroscopy
Godlewska BR, Yip SW, Near J, Goodwin GM, Cowen PJ. Cortical glutathione levels in young people with bipolar disorder: a pilot study using magnetic resonance spectroscopy. Psychopharmacology 2013, 231: 327-332. PMID: 23955702, DOI: 10.1007/s00213-013-3244-0.Peer-Reviewed Original ResearchConceptsBipolar disorderGSH levelsOccipital cortexHealthy age-matched controlsPilot studyDSM-IV bipolar disorderPost-mortem brain tissueConclusionsThis pilot studyAge-matched controlsProton magnetic resonance spectroscopyTime of studyMagnetic resonance spectroscopyCortical GSHIll patientsCortical metabolitesΓ-aminobutyric acidCellular free radicalsMood disturbanceUseful biomarkerBipolar pathophysiologyPatientsTrait biomarkerBrain tissueGlutathione levelsObjectivesThe objective