2024
Cocaine self-administration behavior is associated with subcortical and cortical morphometry measures in individuals with cocaine use disorder
Kohler R, Zhornitsky S, Potenza M, Yip S, Worhunsky P, Angarita G. Cocaine self-administration behavior is associated with subcortical and cortical morphometry measures in individuals with cocaine use disorder. The American Journal Of Drug And Alcohol Abuse 2024, 50: 345-356. PMID: 38551365, PMCID: PMC11305926, DOI: 10.1080/00952990.2024.2318585.Peer-Reviewed Original ResearchGray-matter volumeSelf-administer cocaineSelf-administration behaviorCocaine use disorderSelf-administrationGray-matterFrontal cortexUse disorderCocaine self-administration behaviorSelf-administered cocaine infusionsCocaine self-administrationSelf-administration paradigmInfusions self-administeredSelf-report assessmentsCortical brain regionsStructural MRI dataFR1 scheduleInsular thicknessCocaine infusionsPredisposing vulnerabilitiesCocaine consumptionCocaine useBrain regionsBilateral regionsLimbic system
2015
Prenatal cocaine exposure, illicit-substance use and stress and craving processes during adolescence
Yip SW, Lacadie CM, Sinha R, Mayes LC, Potenza MN. Prenatal cocaine exposure, illicit-substance use and stress and craving processes during adolescence. Drug And Alcohol Dependence 2015, 158: 76-85. PMID: 26627911, PMCID: PMC4698087, DOI: 10.1016/j.drugalcdep.2015.11.012.Peer-Reviewed Original ResearchConceptsPrenatal cocaine exposureIllicit substance useNeural responsesCocaine exposureFunctional neural responsesFunctional magnetic resonance imaging (fMRI) dataDifferent neural substratesOngoing longitudinal studyThree-way interactionCortical brain regionsCue conditionImagery scriptsPCE statusAdolescent developmentStress processingNeural substratesIllicit substance usersPrefrontal cortexRight insulaMagnetic resonance imaging dataNeural activityUtero cocaine exposureSubjective ratingsCortical activityOpposite pattern