2018
Trichuris muris whey acidic protein induces type 2 protective immunity against whipworm
Briggs N, Wei J, Versteeg L, Zhan B, Keegan B, Damania A, Pollet J, Hayes KS, Beaumier C, Seid CA, Leong J, Grencis RK, Bottazzi ME, Sastry KJ, Hotez PJ. Trichuris muris whey acidic protein induces type 2 protective immunity against whipworm. PLOS Pathogens 2018, 14: e1007273. PMID: 30153307, PMCID: PMC6130879, DOI: 10.1371/journal.ppat.1007273.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseImmune correlatesLymph nodesProtective immunityT helper type 2 immune responseT. murisType 2 immune responsesIgE-mediated allergic responsesTh2 cytokines IL-4Adult T. murisAntigen-specific productionCellular immune correlatesHumoral immune correlatesMesenteric lymph nodesInguinal lymph nodesMontanide ISA 720Cytokines IL-4Control of infectionLow drug efficacySubcutaneous vaccineBowel diseaseInfectious causesOral challengeISA 720Protective efficacy
2014
Advancing a multivalent ‘Pan-anthelmintic’ vaccine against soil-transmitted nematode infections
Zhan B, Beaumier CM, Briggs N, Jones KM, Keegan BP, Bottazzi ME, Hotez PJ. Advancing a multivalent ‘Pan-anthelmintic’ vaccine against soil-transmitted nematode infections. Expert Review Of Vaccines 2014, 13: 321-331. PMID: 24392641, PMCID: PMC3934375, DOI: 10.1586/14760584.2014.872035.Peer-Reviewed Original ResearchConceptsSoil-transmitted nematode infectionsPhase 1 clinical testingAntigen selectionHelminth-endemic regionsSabin Vaccine Institute Product Development PartnershipAntigen-specific IgEHuman hookworm vaccineProtective immunityHookworm infectionHookworm vaccinePreclinical evaluationClinical developmentClinical testingAntigen discoveryNematode infectionVaccineInfectionAntigenProduct development partnershipsAscaris eggsIgEAscariasisTrichuriasisAscarisImmunity