2017
Yeast-expressed recombinant As16 protects mice against Ascaris suum infection through induction of a Th2-skewed immune response
Wei J, Versteeg L, Liu Z, Keegan B, Gazzinelli-Guimarães AC, Fujiwara RT, Briggs N, Jones KM, Strych U, Beaumier CM, Bottazzi ME, Hotez PJ, Zhan B. Yeast-expressed recombinant As16 protects mice against Ascaris suum infection through induction of a Th2-skewed immune response. PLOS Neglected Tropical Diseases 2017, 11: e0005769. PMID: 28708895, PMCID: PMC5529013, DOI: 10.1371/journal.pntd.0005769.Peer-Reviewed Original ResearchConceptsTh2-skewed immune responseTh2-type responseCholera toxin B subunitImmune responseEgg challengeProtective immunitySignificant protectionPredominant Th2-type responseTh2-type immune responseFeasible vaccine candidateTh1-type responseCommon helminth infectionA. suum infectionAscaris suum infectionExact protective mechanismHost immune systemToxin B subunitA. suumRestimulated splenocytesA. suum eggsChallenge infectionIL-4IL-5Trichuris infectionHelminth infections
2014
Advancing a multivalent ‘Pan-anthelmintic’ vaccine against soil-transmitted nematode infections
Zhan B, Beaumier CM, Briggs N, Jones KM, Keegan BP, Bottazzi ME, Hotez PJ. Advancing a multivalent ‘Pan-anthelmintic’ vaccine against soil-transmitted nematode infections. Expert Review Of Vaccines 2014, 13: 321-331. PMID: 24392641, PMCID: PMC3934375, DOI: 10.1586/14760584.2014.872035.Peer-Reviewed Original ResearchConceptsSoil-transmitted nematode infectionsPhase 1 clinical testingAntigen selectionHelminth-endemic regionsSabin Vaccine Institute Product Development PartnershipAntigen-specific IgEHuman hookworm vaccineProtective immunityHookworm infectionHookworm vaccinePreclinical evaluationClinical developmentClinical testingAntigen discoveryNematode infectionVaccineInfectionAntigenProduct development partnershipsAscaris eggsIgEAscariasisTrichuriasisAscarisImmunity