2006
Granzyme B‐dependent Matrix Degradation Generates Anti‐Angiostatic Activity in Scleroderma Patients
Mulligan‐Kehoe M, Drinane M, Hummers L, Hall A, Rosen A, Wigley F, Simons M. Granzyme B‐dependent Matrix Degradation Generates Anti‐Angiostatic Activity in Scleroderma Patients. The FASEB Journal 2006, 20: a1099-a1099. DOI: 10.1096/fasebj.20.5.a1099-a.Peer-Reviewed Original ResearchSSc patientsRA patientsScleroderma patientsGranzyme BSystemic connective tissue diseasesExtensive vascular componentConnective tissue diseasePAI-1 levelsNormal control patientsAngiostatin K1-3Impaired wound healingAnti-angiogenic factorsAnti-angiogenic activityNormal endothelial cellsAberrant microvasculatureControl patientsRheumatoid arthritisTissue diseaseVascular abnormalitiesUncertain etiologyVascular componentPatientsEndothelial cellsEndothelial cell migrationWound healing
1999
Local Perivascular Delivery of Basic Fibroblast Growth Factor in Patients Undergoing Coronary Bypass Surgery
Laham R, Sellke F, Edelman E, Pearlman J, Ware J, Brown D, Gold J, Simons M. Local Perivascular Delivery of Basic Fibroblast Growth Factor in Patients Undergoing Coronary Bypass Surgery. Circulation 1999, 100: 1865-1871. PMID: 10545430, DOI: 10.1161/01.cir.100.18.1865.Peer-Reviewed Original ResearchMeSH KeywordsAlginatesCoronary Artery BypassCoronary VesselsDelayed-Action PreparationsDouble-Blind MethodDrug CarriersDrug CompoundingDrug ImplantsFemaleFibroblast Growth Factor 2Follow-Up StudiesGlucuronic AcidHeparinHexuronic AcidsHumansMaleMiddle AgedPatient SelectionPlacebosRecombinant ProteinsConceptsBasic fibroblast growth factorBFGF groupFibroblast growth factorTreatment-related adverse eventsQ-wave myocardial infarctionGrowth factorLocal perivascular deliverySerum bFGF levelsPlacebo-controlled studyCoronary bypass surgerySubset of patientsMode of therapyMagnetic resonance assessmentPromising treatment strategyNuclear perfusionOperative deathsRecurrent anginaStandard revascularizationNew blood vesselsPlacebo groupRepeat revascularizationAdverse eventsBypass surgeryControl patientsPerivascular delivery