2024
Structural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment
McCurdy L, DeVito E, Loya J, Nich C, Zhai Z, Kiluk B, Potenza M. Structural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment. Drug And Alcohol Dependence Reports 2024, 11: 100246. PMID: 38966567, PMCID: PMC11222934, DOI: 10.1016/j.dadr.2024.100246.Peer-Reviewed Original ResearchCocaine use disorderCognitive behavioral therapyCocaine useBehavioral therapyBrain changesBrain structuresWhole-brain voxel-based morphometry analysisCocaine use disorder treatmentLevel of cocaine useWeeks of outpatient treatmentVoxel-based morphometry analysisDigital cognitive behavioral therapyT1-weighted magnetic resonance imaging scansRight caudate bodyAssociated with cocaine useMethadone-maintained individualsGray matter volumeStructural brain changesFunction of engagementCaudate bodyRight caudateCUD treatmentMatter volumeUse disorderBilateral cerebellum
2023
Neural correlates of negative life events and their relationships with alcohol and cannabis use initiation
Zhao Y, Potenza M, Tapert S, Paulus M. Neural correlates of negative life events and their relationships with alcohol and cannabis use initiation. Dialogues In Clinical Neuroscience 2023, 25: 112-121. PMID: 37916739, PMCID: PMC10623894, DOI: 10.1080/19585969.2023.2252437.Peer-Reviewed Original ResearchConceptsNegative life eventsCannabis initiationGreater cortical thicknessCaudate gray matter volumeGray matter volumeDose-response relationshipOdds of alcoholLife eventsInitiation of alcoholSubstance Use InitiationCortical thicknessSubstance-naïveSuperior temporal sulcusNeural pathwaysCannabis useBrain structuresAlcohol useUse initiationAlcohol initiationSubstance use trajectoriesPoor academic performanceTemporal sulcusNeural mechanismsCannabisLinear regression modelsBrain structural co-development is associated with internalizing symptoms two years later in the ABCD cohort
Zhao Y, Paulus M, Potenza M. Brain structural co-development is associated with internalizing symptoms two years later in the ABCD cohort. Journal Of Behavioral Addictions 2023, 12: 80-93. PMID: 36940096, PMCID: PMC10260217, DOI: 10.1556/2006.2023.00006.Peer-Reviewed Original ResearchConceptsScreen media activitiesGray matter volumeInternalizing problemsTwo yearsSymptoms two yearsTwo-year followInferior temporal regionsCortical thickness measuresHours/dayLongitudinal brain imagingInternalizing psychopathologyABCD cohortSmall effect sizesFuture internalizing problemsInternalizing behaviorsExternalizing psychopathologyInferior parietalMediation analysisBrain patternsBrain featuresGreater riskLinear mixed-effects modelsTemporal regionsAge 9Thickness measures