2001
Persistent infection in Neotoma fuscipes (Muridae: Sigmodontinae) with Ehrlichia phagocytophila sensu lato.
Castro M, Nicholson W, Kramer V, Childs J. Persistent infection in Neotoma fuscipes (Muridae: Sigmodontinae) with Ehrlichia phagocytophila sensu lato. American Journal Of Tropical Medicine And Hygiene 2001, 65: 261-7. PMID: 11693866, DOI: 10.4269/ajtmh.2001.65.261.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialArachnid VectorsBase SequenceBorrelia burgdorferiCaliforniaDisease ReservoirsDNA, BacterialEhrlichiaEhrlichiosisFemaleFluorescent Antibody Technique, IndirectHeat-Shock ProteinsHumansIxodesMaleMicePolymerase Chain ReactionRatsRodent DiseasesSeasonsSeroepidemiologic StudiesSigmodontinaeZoonosesConceptsPolymerase chain reaction testingGroESL heat shock operonPersistent infectionReaction testingRatsE. phagocytophilaLyme diseaseBorrelia burgdorferiMiceSeropositive animalsDusky-footed wood ratsPCRWood ratsSeroreversionSensu latoSeroconversionSeropositiveBiopsySerologySeroreactivityInfectionDiseaseBloodAdult Ixodes pacificus CooleySerum
2000
Experimental evidence of host specificity of Bartonella infection in rodents
Kosoy M, Saito E, Green D, Marston E, Jones D, Childs J. Experimental evidence of host specificity of Bartonella infection in rodents. Comparative Immunology Microbiology And Infectious Diseases 2000, 23: 221-238. PMID: 11038125, DOI: 10.1016/s0147-9571(99)00075-2.Peer-Reviewed Original ResearchIsolation of lactate dehydrogenase-elevating viruses from wild house mice and their biological and molecular characterization
Li K, Schuler T, Chen Z, Glass G, Childs J, Plagemann P. Isolation of lactate dehydrogenase-elevating viruses from wild house mice and their biological and molecular characterization. Virus Research 2000, 67: 153-162. PMID: 10867194, DOI: 10.1016/s0168-1702(00)00142-8.Peer-Reviewed Original Research
1999
Population Dynamics of a Naturally Occurring Heterogeneous Mixture of Borrelia burgdorferiClones
Hofmeister E, Glass G, Childs J, Persing D. Population Dynamics of a Naturally Occurring Heterogeneous Mixture of Borrelia burgdorferiClones. Infection And Immunity 1999, 67: 5709-5716. PMID: 10531219, PMCID: PMC96945, DOI: 10.1128/iai.67.11.5709-5716.1999.Peer-Reviewed Original ResearchConceptsC3H/HeJ miceC.B-17 miceLarval Ixodes scapularis ticksMajority of miceB. burgdorferiInfected nymphal ticksIxodes scapularis ticksBurgdorferi antibodiesSecondary challengeHeJ micePrimary isolatesSequential isolatesC3H miceSequential infectionMiceMonoclonal antibodiesBorrelia burgdorferiC expressionScapularis ticksClonal dominanceUnique isolatesMacrorestriction analysisOspC proteinsClonal groupsEnzootic siteRats of the Genus Rattus are Reservoir Hosts for Pathogenic Bartonella Species: An Old World Origin for a New World Disease?
Ellis B, Regnery R, Beati L, Bacellar F, Rood M, Glass G, Marston E, Ksiazek T, Jones D, Childs J. Rats of the Genus Rattus are Reservoir Hosts for Pathogenic Bartonella Species: An Old World Origin for a New World Disease? The Journal Of Infectious Diseases 1999, 180: 220-224. PMID: 10353885, DOI: 10.1086/314824.Peer-Reviewed Original ResearchMolecular Cloning and Characterization of the Ehrlichia chaffeensis Variable-Length PCR Target: an Antigen-Expressing Gene That Exhibits Interstrain Variation
Sumner J, Childs J, Paddock C. Molecular Cloning and Characterization of the Ehrlichia chaffeensis Variable-Length PCR Target: an Antigen-Expressing Gene That Exhibits Interstrain Variation. Journal Of Clinical Microbiology 1999, 37: 1447-1453. PMID: 10203503, PMCID: PMC84798, DOI: 10.1128/jcm.37.5.1447-1453.1999.Peer-Reviewed Original ResearchConceptsOpen reading frameAmino acid sequenceApparent molecular massE. chaffeensisGenomic libraryMolecular cloningReading frameAcid sequenceDifferentiation of isolatesPCR targetsClose homologyMolecular massNucleotide sequencingImmunoreactive proteinDifferent isolatesDNA samplesInterstrain variationGenesRepeat unitsMolecular databasesCell culturesAmblyomma americanum ticksSequencePCR detectionChaffeensisLongitudinal study of infection with Borrelia burgdorferi in a population of Peromyscus leucopus at a Lyme disease-enzootic site in Maryland.
Hofmeister E, Ellis B, Glass G, Childs J. Longitudinal study of infection with Borrelia burgdorferi in a population of Peromyscus leucopus at a Lyme disease-enzootic site in Maryland. American Journal Of Tropical Medicine And Hygiene 1999, 60: 598-609. PMID: 10348235, DOI: 10.4269/ajtmh.1999.60.598.Peer-Reviewed Original ResearchConceptsPolymerase chain reactionB. burgdorferiJuvenile miceCross-sectional sampleEar tissueBorrelia burgdorferi infectionIxodes scapularis ticksInfected miceSusceptible miceChronic infectionOverall prevalenceIncidence rateBurgdorferi infectionHigh riskLower riskInfectionMiceInfected ticksLongitudinal sampleBorrelia burgdorferiScapularis ticksChain reactionBurgdorferiLongitudinal studyIndirect transmissionLong-Term Studies of Hantavirus Reservoir Populations in the Southwestern United States: A Synthesis - Volume 5, Number 1—February 1999 - Emerging Infectious Diseases journal - CDC
Mills J, Ksiazek T, Peters C, Childs J. Long-Term Studies of Hantavirus Reservoir Populations in the Southwestern United States: A Synthesis - Volume 5, Number 1—February 1999 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 1999, 5: 135-142. PMID: 10081681, PMCID: PMC2627702, DOI: 10.3201/eid0501.990116.Peer-Reviewed Original ResearchConceptsInfectious Diseases journal - CDCAdult male rodentsPrevalence of infectionPattern of infectionHigh prevalencePersistent infectionOld miceHantavirus infectionMale rodentsHantavirus antibodiesInfectionMeasurable associationHantavirus transmissionPrevalenceHantavirus reservoir populationsVirus transmissionTerm studiesHorizontal transmissionInfection dynamicsUnited StatesRodentsReservoir populationsPopulationAssociationImportant differences
1998
Black Creek Canal Virus infection in Sigmodon hispidus in southern Florida.
Glass G, Livingstone W, Mills J, Hlady W, Fine J, Biggler W, Coke T, Frazier D, Atherley S, Rollin P, Ksiazek T, Peters C, Childs J. Black Creek Canal Virus infection in Sigmodon hispidus in southern Florida. American Journal Of Tropical Medicine And Hygiene 1998, 59: 699-703. PMID: 9840584, DOI: 10.4269/ajtmh.1998.59.699.Peer-Reviewed Original Research
1997
Distribution, diversity, and host specificity of Bartonella in rodents from the Southeastern United States.
Kosoy M, Regnery R, Tzianabos T, Marston E, Jones D, Green D, Maupin G, Olson J, Childs J. Distribution, diversity, and host specificity of Bartonella in rodents from the Southeastern United States. American Journal Of Tropical Medicine And Hygiene 1997, 57: 578-88. PMID: 9392599, DOI: 10.4269/ajtmh.1997.57.578.Peer-Reviewed Original ResearchConceptsPhylogenetic groupsHost specificityDistinct phylogenetic groupsCitrate synthase geneSpecies of PeromyscusMajor biotic communitiesSpecies of rodentsSoutheastern United StatesDegree of homologyRodent communitiesSynthase geneWild-caught rodentsBiotic communitiesSequence homologyBartonella isolatesSequence analysisBartonellaSpeciesHomologyGenotypic groupsGenotypic variantsGeographic sitesSingle siteRodentsGenesExperimental evaluation of rodent exclusion methods to reduce hantavirus transmission to humans in rural housing.
Glass G, Johnson J, Hodenbach G, Disalvo C, Peters C, Childs J, Mills J. Experimental evaluation of rodent exclusion methods to reduce hantavirus transmission to humans in rural housing. American Journal Of Tropical Medicine And Hygiene 1997, 56: 359-64. PMID: 9158040, DOI: 10.4269/ajtmh.1997.56.359.Peer-Reviewed Original Research
1996
Characterization of Oliveros virus, a new member of the Tacaribe complex (Arenaviridae: Arenavirus).
Mills J, Barrera Oro J, Bressler D, Childs J, Tesh R, Smith J, Enria D, Geisbert T, McKee K, Bowen M, Peters C, Jahrling P. Characterization of Oliveros virus, a new member of the Tacaribe complex (Arenaviridae: Arenavirus). American Journal Of Tropical Medicine And Hygiene 1996, 54: 399-404. PMID: 8615455, DOI: 10.4269/ajtmh.1996.54.399.Peer-Reviewed Original ResearchAnimalsAnimals, SucklingArenaviruses, New WorldArgentinaChlorocebus aethiopsCross ReactionsCytopathogenic Effect, ViralDisease ReservoirsElectrophoresis, Polyacrylamide GelFluorescent Antibody TechniqueHemorrhagic Fever, AmericanMiceMice, Inbred ICRMicroscopy, ElectronNeutralization TestsRodent DiseasesSigmodontinaeVero CellsViral ProteinsVirion
1995
Analysis of Borrelia burgdorferi Sequentially Isolated from Peromyscus leucopus Captured at a Lyme Disease Enzootic Site
Hofmeister E, Childs J. Analysis of Borrelia burgdorferi Sequentially Isolated from Peromyscus leucopus Captured at a Lyme Disease Enzootic Site. The Journal Of Infectious Diseases 1995, 172: 462-469. PMID: 7622890, DOI: 10.1093/infdis/172.2.462.Peer-Reviewed Original ResearchIsolation of black creek canal virus, a new hantavirus from Sigmodon hispidus in Florida
Rollin P, Ksiazek T, Elliott L, Ravkov E, Martin M, Morzunov S, Livingstone W, Monroe M, Glass G, Ruo S, Khan A, Childs J, Nichol S, Peters C. Isolation of black creek canal virus, a new hantavirus from Sigmodon hispidus in Florida. Journal Of Medical Virology 1995, 46: 35-39. PMID: 7623004, DOI: 10.1002/jmv.1890460108.Peer-Reviewed Original ResearchConceptsBlack Creek Canal virusReverse transcriptase-polymerase chain reaction assaysNew hantavirusCotton ratsTranscriptase-polymerase chain reaction assaysVero E6 cellsHantavirus pulmonary syndrome casesVirologic studiesChain reaction assaysHantavirus antigensHigh seroprevalenceSyndrome casesE6 cellsSpleen homogenatesRT-PCRReaction assaysDirect RT-PCRVirusSerologic relationshipHantavirusesRatsRodentsSigmodon hispidusDade CountySeroprevalence
1994
Isolation of the causative agent of hantavirus pulmonary syndrome.
Elliott L, Ksiazek T, Rollin P, Spiropoulou C, Morzunov S, Monroe M, Goldsmith C, Humphrey C, Zaki S, Krebs J, Maupin G, Gage K, Childs J, Nichol S, Peters C. Isolation of the causative agent of hantavirus pulmonary syndrome. American Journal Of Tropical Medicine And Hygiene 1994, 51: 102-8. PMID: 8059907, DOI: 10.4269/ajtmh.1994.51.102.Peer-Reviewed Original ResearchConceptsHantavirus pulmonary syndromePulmonary syndromeAcute respiratory illnessReverse transcriptase-polymerase chain reactionCausative agentTypical morphologic featuresConvalescent-phase seraTranscriptase-polymerase chain reactionUnknown hantavirusRespiratory illnessLung tissueHPS patientsVirus antigenEtiologic agentHigh mortalityMorphologic featuresIndirect immunofluorescenceGenus HantavirusVero cellsInfected cellsChain reactionRecent outbreakCell linesSyndromeDeer mice
1992
Comparison of polymerase chain reaction and culture for detection of Borrelia burgdorferi in naturally infected Peromyscus leucopus and experimentally infected C.B-17 scid/scid mice
Hofmeister E, Markham R, Childs J, Arthur R. Comparison of polymerase chain reaction and culture for detection of Borrelia burgdorferi in naturally infected Peromyscus leucopus and experimentally infected C.B-17 scid/scid mice. Journal Of Clinical Microbiology 1992, 30: 2625-2631. PMID: 1400962, PMCID: PMC270489, DOI: 10.1128/jcm.30.10.2625-2631.1992.Peer-Reviewed Original ResearchLymphocytic choriomeningitis virus infection and house mouse (Mus musculus) distribution in urban Baltimore.
Childs J, Glass G, Korch G, Ksiazek T, Leduc J. Lymphocytic choriomeningitis virus infection and house mouse (Mus musculus) distribution in urban Baltimore. American Journal Of Tropical Medicine And Hygiene 1992, 47: 27-34. PMID: 1636880, DOI: 10.4269/ajtmh.1992.47.27.Peer-Reviewed Original Research
1991
Human-rodent contact and infection with lymphocytic choriomeningitis and Seoul viruses in an inner-city population.
Childs J, Glass G, Ksiazek T, Rossi C, Oro J, Leduc J. Human-rodent contact and infection with lymphocytic choriomeningitis and Seoul viruses in an inner-city population. American Journal Of Tropical Medicine And Hygiene 1991, 44: 117-21. PMID: 1672798, DOI: 10.4269/ajtmh.1991.44.117.Peer-Reviewed Original ResearchConceptsLymphocytic choriomeningitis virusSeoul virusRodent-borne virusesHuman-rodent contactHistory of travelInner-city populationDisease clinicRodent exposureLymphocytic choriomeningitisAntibody prevalenceNeutralization testSerological testsAntibodiesVirusHigh rateInfectionRatsMore exposureExposureQuestionnaire responsesChoriomeningitisClinicPrevalenceMicePersons
1987
Prospective seroepidemiology of hantaviruses and population dynamics of small mammal communities of Baltimore, Maryland.
Childs J, Glass G, Korch G, LeDuc J. Prospective seroepidemiology of hantaviruses and population dynamics of small mammal communities of Baltimore, Maryland. American Journal Of Tropical Medicine And Hygiene 1987, 37: 648-62. PMID: 2891308, DOI: 10.4269/ajtmh.1987.37.648.Peer-Reviewed Original ResearchConceptsHigh IFA titersProspective seroepidemiological studyIndirect fluorescent antibody titersFluorescent antibody titersEvidence of transmissionTransmission of hantavirusesIndividual blood samplesAntibody titersSeroepidemiological studyIncidence rateAntibody prevalenceBlood samplesIFA titersMean incidenceRatsVirus transmissionHantavirusesMature animalsWhite-footed miceMiceTitersMonthsRodents