2024
Gene trajectory inference for single-cell data by optimal transport metrics
Qu R, Cheng X, Sefik E, Stanley III J, Landa B, Strino F, Platt S, Garritano J, Odell I, Coifman R, Flavell R, Myung P, Kluger Y. Gene trajectory inference for single-cell data by optimal transport metrics. Nature Biotechnology 2024, 1-11. PMID: 38580861, PMCID: PMC11452571, DOI: 10.1038/s41587-024-02186-3.Peer-Reviewed Original ResearchGene dynamicsGene programTrajectory inferenceBiological processesCell-cell graphDynamics of genesCell trajectory inferenceSingle-cell RNA sequencingSingle-cell dataCell state transitionsMyeloid lineage maturationDynamics of biological processesGene distributionRNA sequencingPseudotemporal orderingGene processingTrajectories of cellsGenesActivity of biological processesTechnical noiseGroups of cellsLineage maturationCellsConstruct cellsSequence
2016
Microbiome: Ecology of eczema
Odell ID, Flavell RA. Microbiome: Ecology of eczema. Nature Microbiology 2016, 1: 16135. PMID: 27562264, PMCID: PMC6035744, DOI: 10.1038/nmicrobiol.2016.135.Peer-Reviewed Original Research
2005
A systematic RNAi screen for longevity genes in C. elegans
Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS. A systematic RNAi screen for longevity genes in C. elegans. Genes & Development 2005, 19: 1544-1555. PMID: 15998808, PMCID: PMC1172061, DOI: 10.1101/gad.1308205.Peer-Reviewed Original ResearchConceptsLongevity genesGenome-wide functional genomics screenDAF-16/FOXO transcription factorRNA interferenceDAF-16/FOXONew longevity genesSystematic RNAi screenFunctional genomic screensFOXO transcription factorsLarge-scale RNA interferenceCandidate longevity genesRNAi inactivationAnimal phylogenyRNAi screenC. elegansGenetic interactionsGenomic screenSignal transductionTranscription factorsDaf-2Gene expressionProtein deacetylaseProtein turnoverGenesPathway