Clinical characteristics associated with Spitz nevi and Spitzoid malignant melanomas: The Yale University Spitzoid Neoplasm Repository experience, 1991 to 2008
Lott JP, Wititsuwannakul J, Lee JJ, Ariyan S, Narayan D, Kluger HH, Lazova R. Clinical characteristics associated with Spitz nevi and Spitzoid malignant melanomas: The Yale University Spitzoid Neoplasm Repository experience, 1991 to 2008. Journal Of The American Academy Of Dermatology 2014, 71: 1077-1082. PMID: 25308882, PMCID: PMC6133655, DOI: 10.1016/j.jaad.2014.08.026.Peer-Reviewed Original ResearchConceptsMalignant melanomaSpitzoid malignant melanomasSpitz neviClinical characteristicsRetrospective cohort studyMultivariate logistic regressionMalignant melanoma diagnosisSelect patientsCohort studyYounger patientsClinical featuresSingle institutionMale genderMelanomaSmall lesionsLogistic regressionNeviSmall sample sizeLesionsMelanoma diagnosisDiagnosisUnmeasured confoundingPatientsDescriptive statisticsAgeMEK targeting in N-RAS mutated metastatic melanoma
Thumar J, Shahbazian D, Aziz SA, Jilaveanu LB, Kluger HM. MEK targeting in N-RAS mutated metastatic melanoma. Molecular Cancer 2014, 13: 45. PMID: 24588908, PMCID: PMC3945937, DOI: 10.1186/1476-4598-13-45.Peer-Reviewed Original ResearchConceptsN-RASShort-term cultureMelanoma patientsMelanoma culturesYale Cancer CenterMetastatic melanoma patientsTime of presentationOngoing clinical trialsProtein kinase pathway activationN-RAS mutationsB-RafPan-RAF inhibitorTerm cultureKinase pathway activationConclusionsThe prognosisBrain metastasesClinical characteristicsMetastatic diseasePathologic dataWorse prognosisCancer CenterMetastatic melanomaClinical trialsMutant melanomaMelanoma cell cultures