2023
Identifying psychosis subtypes use individualized covariance structural differential networks and multi-site clustering
Ji Y, Pearlson G, Bustillo J, Kochunov P, Turner J, Jiang R, Shao W, Zhang X, Fu Z, Li K, Liu Z, Xu X, Zhang D, Qi S, Calhoun V. Identifying psychosis subtypes use individualized covariance structural differential networks and multi-site clustering. Schizophrenia Research 2023, 264: 130-139. PMID: 38128344, DOI: 10.1016/j.schres.2023.12.013.Peer-Reviewed Original ResearchPsychosis subtypesSchizoaffective disorderBipolar disorderClinical phenotypeFirst-degree relativesTemporal-occipital cortexAmygdala-hippocampusClinical symptomsNeuroimaging featuresBipolar-Schizophrenia NetworkBrain alterationsHealthy controlsIntermediate Phenotypes (B-SNIP) consortiumOccipital cortexDecreased connectivitySubtypesStructural covarianceFractional amplitudeSubtype IILow-frequency fluctuationsNeurobiological heterogeneityGreater predispositionPsychosis spectrumGroup differencesDiagnostic classification
2020
Effects of Stimulus Repetition on Emotional Processing in Psychosis Biotypes: Findings From Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) Consortium
Abdelmageed S, Trotti R, Parker D, Sabatinelli D, Tamminga C, Gershon E, Keedy S, Sweeney J, Keshavan M, Pearlson G, McDowell J, Clementz B. Effects of Stimulus Repetition on Emotional Processing in Psychosis Biotypes: Findings From Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) Consortium. Biological Psychiatry 2020, 87: s389. DOI: 10.1016/j.biopsych.2020.02.996.Peer-Reviewed Original Research
2019
Intrinsic neural activity differences in psychosis biotypes: Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium
Thomas O, Parker D, Trotti R, McDowell J, Gershon E, Sweeney J, Keshavan M, Keedy S, Ivleva E, Tamminga C, Pearlson G, Clementz B. Intrinsic neural activity differences in psychosis biotypes: Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium. Biomarkers In Neuropsychiatry 2019, 1: 100002. PMID: 36643612, PMCID: PMC9837786, DOI: 10.1016/j.bionps.2019.100002.Peer-Reviewed Original ResearchPsychosis biotypesHealthy personsBipolar-Schizophrenia NetworkSingle-trial powerFirst-degree biological relativesNeural activity differencesInter-stimulus intervalBiotype 2Intermediate Phenotypes (B-SNIP) consortiumPsychosis casesEffective treatmentIntrinsic activityPsychosis subgroupsNeural modulationLow intrinsic activityDSM groupNeural activitySocial functioningBiotype characterizationBiological relativesConventional diagnosisIntermediate phenotypesDifferentiating featuresDSM syndromesProbands
2018
S188. Emotional processing in Bipolar Disorder With and Without Psychosis: Findings From the Psychosis and Affective Research Domains and Intermediate Phenotypes Consortium
Trotti R, Parker D, Sabatinelli D, Tamminga C, Gershon E, Keedy S, Sweeney J, Keshavan M, Pearlson G, McDowell J, Clementz B. S188. Emotional processing in Bipolar Disorder With and Without Psychosis: Findings From the Psychosis and Affective Research Domains and Intermediate Phenotypes Consortium. Biological Psychiatry 2018, 83: s420. DOI: 10.1016/j.biopsych.2018.02.1080.Peer-Reviewed Original Research148. Auditory and Visual EEG Validators of Psychosis Biotypes, Findings From Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) Consortium
Parker D, Trotti R, McDowell J, Keedy S, Sweeney J, Gershon E, Pearlson G, Keshavan M, Tamminga C, Clementz B. 148. Auditory and Visual EEG Validators of Psychosis Biotypes, Findings From Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) Consortium. Biological Psychiatry 2018, 83: s60-s61. DOI: 10.1016/j.biopsych.2018.02.166.Peer-Reviewed Original ResearchT22. PITUITARY GLAND VOLUME DIFFERENCES IN INDIVIDUALS WITH PSYCHOSIS: RESULTS FROM THE BIPOLAR-SCHIZOPHRENIA NETWORK ON INTERMEDIATE PHENOTYPES (B-SNIP) STUDY
Guimond S, Tingue S, Devenyi G, Tang Y, Mike L, Chakravarty M, Sweeney J, Pearlson G, Clementz B, Tamminga C, Keshavan M. T22. PITUITARY GLAND VOLUME DIFFERENCES IN INDIVIDUALS WITH PSYCHOSIS: RESULTS FROM THE BIPOLAR-SCHIZOPHRENIA NETWORK ON INTERMEDIATE PHENOTYPES (B-SNIP) STUDY. Schizophrenia Bulletin 2018, 44: s121-s121. PMCID: PMC5888564, DOI: 10.1093/schbul/sby016.298.Peer-Reviewed Original ResearchPituitary gland volumeLarger pituitary glandsDuration of illnessHealthy controlsGland volumePituitary glandPsychotic bipolar disorderSymptom severityBipolar-Schizophrenia NetworkPituitary volumeSchizoaffective disorderLarger pituitary gland volumesClinical diagnosisLarger pituitary volumeSubgroup of patientsSignificant main effectGreater symptom severitySignificant subgroup differencesIndependent t-testAdrenal axisPatient groupIntermediate Phenotypes (B-SNIP) consortiumMAGeT Brain algorithmStructural magnetic resonance imagesIntermediate Phenotypes (B-SNIP) study
2017
M94. Genetic Analyses of Cognitive Performance in Psychotic Disorders From the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) Consortium
Bishop J, Hill S, Mills L, Alliey-Rodriguez N, Reilly J, Shaffee R, McCarroll S, Keefe R, Pearlson G, Clementz B, Tamminga C, Keshavan M, Gershon E, Sweeney J. M94. Genetic Analyses of Cognitive Performance in Psychotic Disorders From the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) Consortium. Schizophrenia Bulletin 2017, 43: s245-s245. PMCID: PMC5475991, DOI: 10.1093/schbul/sbx022.089.Peer-Reviewed Original ResearchEpigenetic gene regulationQuantitative trait phenotypesGenomes reference panelChromatin regulationGene regulationGWAS approachMicroRNA genesSNP markersTrait phenotypesNumerous SNPsGenetic lociGenetic analysisChromosome 6Allele dosageGenesAfrican ancestryGenetic contributorsSuggestive associationReference panelAncestry groupsLociBrain structuresPsychotic disordersIntermediate Phenotypes (B-SNIP) consortiumSNPs