2017
Multimodal Investigation of Network Level Effects Using Intrinsic Functional Connectivity, Anatomical Covariance, and Structure-to-Function Correlations in Unmedicated Major Depressive Disorder
Scheinost D, Holmes SE, DellaGioia N, Schleifer C, Matuskey D, Abdallah CG, Hampson M, Krystal JH, Anticevic A, Esterlis I. Multimodal Investigation of Network Level Effects Using Intrinsic Functional Connectivity, Anatomical Covariance, and Structure-to-Function Correlations in Unmedicated Major Depressive Disorder. Neuropsychopharmacology 2017, 43: 1119-1127. PMID: 28944772, PMCID: PMC5854800, DOI: 10.1038/npp.2017.229.Peer-Reviewed Original ResearchConceptsMajor depressive disorderAnterior cingulate cortexIntrinsic functional connectivityMedial prefrontal cortexFunctional connectivityLarge-scale brain networksDepressive disorderMDD groupAnatomical covarianceBrain networksUnmedicated major depressive disorderWhole-brain intrinsic functional connectivitySystem-level disorderIntrinsic connectivity distributionRegional brain structureMultiple brain networksAltered connectivityCommon findingHealthy comparison participantsDepressive symptomsAltered volumeUnmedicated individualsLocal circuitryCingulate cortexDepressive symptomatologyFine Motor Skill Mediates Visual Memory Ability with Microstructural Neuro-correlates in Cerebellar Peduncles in Prematurely Born Adolescents
Thomas AR, Lacadie C, Vohr B, Ment LR, Scheinost D. Fine Motor Skill Mediates Visual Memory Ability with Microstructural Neuro-correlates in Cerebellar Peduncles in Prematurely Born Adolescents. Cerebral Cortex 2017, 27: 322-329. PMID: 28108493, PMCID: PMC5939198, DOI: 10.1093/cercor/bhw415.Peer-Reviewed Original ResearchConceptsGrooved Pegboard TestFine motor skillsVisual-motor integrationRey-Osterrieth Complex Figure TestCerebellar peduncleFractional anisotropyBrain injuryGPT scoresMotor skillsBilateral middle cerebellar pedunclesNeonatal brain injuryDiffusion-weighted magnetic resonance imagingRight superior cerebellar peduncleAge 16 yearsSuperior cerebellar peduncleMiddle cerebellar peduncleBeery Visual Motor IntegrationMagnetic resonance imagingRisk of deficitsWhite matter microstructurePegboard TestPretermResonance imagingComplex Figure TestTerm controls
2012
A left cerebellar pathway mediates language in prematurely-born young adults
Constable RT, Vohr BR, Scheinost D, Benjamin JR, Fulbright RK, Lacadie C, Schneider KC, Katz KH, Zhang H, Papademetris X, Ment LR. A left cerebellar pathway mediates language in prematurely-born young adults. NeuroImage 2012, 64: 371-378. PMID: 22982585, PMCID: PMC3508203, DOI: 10.1016/j.neuroimage.2012.09.008.Peer-Reviewed Original ResearchConceptsPT subjectsTerm controlsInferior frontal gyrusFunctional MRIFunctional connectivityResting-state functional MRIYoung adultsCognitive outcomesSeed-based connectivity analysisAge 20 yearsSeed-based analysisAlternative neural pathwaysControl young adultsPreterm subjectsCerebellar connectivityNeural pathwaysCerebellar pathwaysIndex scoreNineteen ptsGray matterMaternal educationQuadrangular lobuleDevelopmental delayPT brainSignificant positive correlation