2000
The Immunologically Protective P-4 Antigen ofLeishmania Amastigotes A DEVELOPMENTALLY REGULATED SINGLE STRAND-SPECIFIC NUCLEASE ASSOCIATED WITH THE ENDOPLASMIC RETICULUM*
Kar S, Soong L, Colmenares M, Goldsmith-Pestana K, McMahon-Pratt D. The Immunologically Protective P-4 Antigen ofLeishmania Amastigotes A DEVELOPMENTALLY REGULATED SINGLE STRAND-SPECIFIC NUCLEASE ASSOCIATED WITH THE ENDOPLASMIC RETICULUM*. Journal Of Biological Chemistry 2000, 275: 37789-37797. PMID: 10969068, DOI: 10.1074/jbc.m002149200.Peer-Reviewed Original ResearchConceptsEndoplasmic reticulumSpecific nuclease activityBlot analysisImmunofluorescence microscopic analysisIntracellular amastigote stageProtein sequence dataSingle-strand nucleasePeripheral blood mononuclear cellsSouthern blot analysisNorthern blot analysisBlood mononuclear cellsMembrane proteinsRNA stabilitySubcellular localizationFuture vaccine studiesDNA repairSequence dataTerminal domainAmerican cutaneous leishmaniasisSequence analysisNuclease activityAmastigote stagePromastigote stageSpecific nucleasesT helper
1998
Leishmania Amastigote Target Antigens: The Challenge of a Stealthy Intracellular Parasite
McMahon-Pratt D, Kima P, Soong L. Leishmania Amastigote Target Antigens: The Challenge of a Stealthy Intracellular Parasite. Trends In Parasitology 1998, 14: 31-34. PMID: 17040687, DOI: 10.1016/s0169-4758(97)01164-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsClass II presentation pathwayAmastigote stageMHC class ILeishmanial vaccineLeishmanial antigensAntigen presentationT cellsElicit protectionImmunized hostsPresentation pathwayInfected macrophagesMolecular vaccinesVaccine targetsInfected mammalian hostsClass IIntracellular parasitesVaccineInfectionCandidate moleculesMacrophagesMammalian hostsDevelopmental formsImmunizationAntigenLeishmaniasis
1993
Developmental Life Cycle of Leishmania—Cultivation and Characterization of Cultured Extracellular Amastigotes1
PAN A, DUBOISE S, EPERON S, RIVAS L, HODGKINSON V, TRAUB‐CSEKO Y, MCMAHON‐PRATT D. Developmental Life Cycle of Leishmania—Cultivation and Characterization of Cultured Extracellular Amastigotes1. Journal Of Eukaryotic Microbiology 1993, 40: 213-223. PMID: 8461895, DOI: 10.1111/j.1550-7408.1993.tb04906.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPlethora of proteinsCultured amastigotesDevelopmental life cycleDevelopmental responsesDevelopmental regulationAxenic cultureAxenic linesAmastigote stageBiochemical evidenceLife cycleInfected macrophagesOrganismsEnvironmental parametersLeishmania promastigotesAmastigotesDevelopmental investigationsLeishmaniaProteinParasitesRegulationBiochemistryLinesLeishmania amastigotesCharacterizationLeishmania organisms
1984
Leishmania mexicana pifanoi: antigenic characterization of promastigote and amastigote stages by solid phase radioimmunoassay.
Pan A, McMahon-Pratt D, Honigberg B. Leishmania mexicana pifanoi: antigenic characterization of promastigote and amastigote stages by solid phase radioimmunoassay. Journal Of Parasitology 1984, 70: 834-5. PMID: 6512649, DOI: 10.2307/3281780.Peer-Reviewed Original ResearchConceptsSolid-phase radioimmunoassayAntigenic characterizationPhase radioimmunoassayAmastigote stage