2015
Mature T cell responses are controlled by microRNA-142
Sun Y, Oravecz-Wilson K, Mathewson N, Wang Y, McEachin R, Liu C, Toubai T, Wu J, Rossi C, Braun T, Saunders T, Reddy P. Mature T cell responses are controlled by microRNA-142. Journal Of Clinical Investigation 2015, 125: 2825-2840. PMID: 26098216, PMCID: PMC4563679, DOI: 10.1172/jci78753.Peer-Reviewed Original ResearchConceptsCell cyclingE2F transcription factorsAtypical E2F transcription factorMature T cell responsesCell proliferationShort palindromic repeatsUpregulation of genesMiR-142T cell developmentTranscription factorsBioinformatics analysisTarget genesPalindromic repeatsMolecular approachesMolecular mechanismsCell developmentMolecular processesMicroRNA-142Targeted deletionWT T cellsGenesE2F8E2F7Multiple murine modelsT cell proliferation
2009
DNMT1 and DNMT3B Modulate Distinct Polycomb-Mediated Histone Modifications in Colon Cancer
Jin B, Yao B, Li J, Fields C, Delmas A, Liu C, Robertson K. DNMT1 and DNMT3B Modulate Distinct Polycomb-Mediated Histone Modifications in Colon Cancer. Cancer Research 2009, 69: 7412-7421. PMID: 19723660, PMCID: PMC2745494, DOI: 10.1158/0008-5472.can-09-0116.Peer-Reviewed Original ResearchConceptsDNA methyltransferasesMethylation patternsPolycomb group targetsPRC1/PRC2DNA methylation patternsBisulfite genomic sequencingPRC1 functionRepression complexHistone codeHistone modificationsChromatin immunoprecipitationEpigenetic silencingPanel of genesEpigenetic modifiersReverse transcription-PCRPRC2DNMT3BNovel linkGenomic sequencingGenesDNMT1Colorectal cancer cell linesCell growthCancer cell linesPRC1
2005
Defective Jak-Stat Activation in Hepatoma Cells Is Associated with Hepatitis C Viral IFN- Resistance
Zhu H, Nelson D, Crawford J, Liu C. Defective Jak-Stat Activation in Hepatoma Cells Is Associated with Hepatitis C Viral IFN- Resistance. Journal Of Interferon & Cytokine Research 2005, 25: 528-539. PMID: 16181053, DOI: 10.1089/jir.2005.25.528.Peer-Reviewed Original ResearchMeSH KeywordsAntiviral AgentsCarcinoma, HepatocellularCell Line, TumorDNA-Binding ProteinsDrug Resistance, ViralHepacivirusHumansInterferon-alphaLiverLiver NeoplasmsMutationProtein-Tyrosine KinasesRepliconRepressor ProteinsSTAT3 Transcription FactorSuppressor of Cytokine Signaling 3 ProteinSuppressor of Cytokine Signaling ProteinsTrans-ActivatorsTranscription FactorsViral Nonstructural ProteinsConceptsIFN resistanceHCV subgenomic replicon cell culture systemViral infectionChronic hepatitis C viral infectionIFN-sensitive cell linesHepatitis C viral infectionIFN stimulationCell linesRibavirin combination therapyMajority of patientsC viral infectionSTAT3 activationResistant cell linesIFN monotherapyIFN therapySuppressor of cytokineCombination therapyIFN sensitivityJAK-STAT activationIFNPotential mechanismsLong-term cultureCell culture systemExhibit alterationsJAK-STAT
1998
Cloning and expression of a cDNA encoding the large subunit of duck replication factor C1Genbank accession number: U60144.1
Guo J, Liu C, Mason W, Pugh J. Cloning and expression of a cDNA encoding the large subunit of duck replication factor C1Genbank accession number: U60144.1. Biochimica Et Biophysica Acta 1998, 1395: 293-300. PMID: 9512663, DOI: 10.1016/s0167-4781(97)00174-7.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsBacteriophage lambdaBase SequenceCloning, MolecularDNA ReplicationDNA-Binding ProteinsDNA, ComplementaryDrosophilaDucksGene LibraryHomeodomain ProteinsHumansLiverMacromolecular SubstancesMiceMinor Histocompatibility AntigensMolecular Sequence DataMolecular WeightProto-Oncogene Proteins c-bcl-2Replication Protein CRepressor ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSequence AlignmentSequence Homology, Amino Acid