2019
Social cognition in schizophrenia: A network-based approach to a Taiwanese version of the Reading the Mind in the Eyes test
Li T, Liu C, Liu C, Hsieh M, Lin Y, Wang E, Hwang T, Chou T. Social cognition in schizophrenia: A network-based approach to a Taiwanese version of the Reading the Mind in the Eyes test. Journal Of The Formosan Medical Association 2019, 119: 439-448. PMID: 31558338, DOI: 10.1016/j.jfma.2019.08.008.Peer-Reviewed Original ResearchConceptsEyes TestNegative emotionsMental statesHealthy controlsSocial cognitive impairmentsChoice patternsStructure of mental statesTaiwanese versionBlunted affectEmotional withdrawalSocial cognitionSocial withdrawalAspect of theoryNegative wordsSchizophreniaEmotionsHigh centralityEmotional aspectsReaction timePoor performanceControl groupImpairmentWithdrawalPatient groupCognition
2018
Trajectories after first‐episode psychosis: Complement to ambiguous outcomes of long‐term antipsychotic treatment by exploring a few hidden cases
Liu C, Lin Y, Liu C, Hsieh M, Chien Y, Hwang T, Hwu H. Trajectories after first‐episode psychosis: Complement to ambiguous outcomes of long‐term antipsychotic treatment by exploring a few hidden cases. Early Intervention In Psychiatry 2018, 13: 895-901. PMID: 29927087, DOI: 10.1111/eip.12696.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisLong-term antipsychotic treatmentAntipsychotic treatmentRecurrence of psychotic symptomsCourse of chronic schizophreniaLow-dose antipsychoticsChronic schizophreniaDysthymic statesPsychotic symptomsDiagnostic stabilityWord lettersRemission criteriaPsychosisAmbiguous informationProbability of relapseCoping strategiesImpending relapseAmbiguous outcomesDiscontinued medicationAntipsychoticsPersonalized formulationsMedication adherencePsychosocial factorsEarly interventionGroup of patientsShared and distinct alterations of white matter tracts in remitted and nonremitted patients with schizophrenia
Huang J, Liu C, Hwang T, Chen Y, Hsu Y, Hwu H, Lin Y, Hsieh M, Liu C, Chien Y, Tseng W. Shared and distinct alterations of white matter tracts in remitted and nonremitted patients with schizophrenia. Human Brain Mapping 2018, 39: 2007-2019. PMID: 29377322, PMCID: PMC6866389, DOI: 10.1002/hbm.23982.Peer-Reviewed Original ResearchConceptsGeneralized fractional anisotropyGeneralized fractional anisotropy valuesAdequate antipsychotic treatmentNegative symptom scoresNonremission groupWhite matter tract integrityWhite matter integrityHealthy controlsRemission stateWhite matter tract bundlesWhite matter tractsReduced integrationAntipsychotic treatmentNonremitted patientsSchizophrenia patientsSymptomatic remissionIllness durationAnalysis of covarianceSchizophreniaDiffusion spectrum imagingTract integrityPost hoc analysisFractional anisotropyMedication dosesEducation years
2015
Primary and secondary alterations of white matter connectivity in schizophrenia: A study on first-episode and chronic patients using whole-brain tractography-based analysis
Wu C, Hwang T, Chen Y, Hsu Y, Lo Y, Liu C, Hwu H, Liu C, Hsieh M, Chien Y, Chen C, Tseng W. Primary and secondary alterations of white matter connectivity in schizophrenia: A study on first-episode and chronic patients using whole-brain tractography-based analysis. Schizophrenia Research 2015, 169: 54-61. PMID: 26443482, DOI: 10.1016/j.schres.2015.09.023.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexBilateral DLPFCFirst-episode patientsWhite matter connectivityFirst-episodeChronic patientsBilateral dorsolateral prefrontal cortexFirst-episode schizophreniaWidespread white matter abnormalitiesBilateral temporal polesDebilitating mental disorderReduced white matter connectivityRight arcuate fasciculusSuperior longitudinal fasciculus IDuration of illnessAssociated with clinical variablesCallosal fibersBetween-group analysisWhite matter tractsWhite matter abnormalitiesPrefrontal cortexImpaired connectivityTemporal poleArcuate fasciculusCerebral white matterNeurocognitive functioning of subjects with putative pre-psychotic states and early psychosis
Liu C, Hua M, Hwang T, Chiu C, Liu C, Hsieh M, Chien Y, Lin Y, Hwu H. Neurocognitive functioning of subjects with putative pre-psychotic states and early psychosis. Schizophrenia Research 2015, 164: 40-46. PMID: 25802138, DOI: 10.1016/j.schres.2015.03.006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCognition DisordersFemaleHumansIntelligence TestsMaleNeuropsychological TestsProdromal SymptomsPsychiatric Status Rating ScalesPsychotic DisordersTaiwanYoung AdultConceptsUltra-high riskPre-psychotic stateNeurocognitive functionWechsler Adult Intelligence Scale-Third EditionWechsler Memory Scale-Third EditionRisk of transition to psychosisWisconsin Card Sorting TestCard Sorting TestDomains of neurocognitionNeurocognitive function of patientsTransition to psychosisContinuous Performance TestVerbal fluency testTrail Making TestLevels of clinical severityFollow-up assessmentStability of changesSorting TestNeuropsychological batteryOnset of illnessNeurocognitive profileEpisode psychosisFluency testNeurocognitive deficitsFunction of subjects
2013
Facial and Prosodic Emotion Recognition Deficits Associate with Specific Clusters of Psychotic Symptoms in Schizophrenia
Tseng H, Chen S, Liu C, Howes O, Huang Y, Hsieh M, Liu C, Shan J, Lin Y, Hwu H. Facial and Prosodic Emotion Recognition Deficits Associate with Specific Clusters of Psychotic Symptoms in Schizophrenia. PLOS ONE 2013, 8: e66571. PMID: 23818944, PMCID: PMC3688591, DOI: 10.1371/journal.pone.0066571.Peer-Reviewed Original ResearchConceptsEmotion recognition abilityCluster of psychotic symptomsPsychotic symptomsEmotion recognition taskHappy emotionHealthy participantsDysfunction of brain systemsSeverity of psychotic symptomsDeficits of emotion recognitionPresentation of psychotic symptomsDSM-IV diagnostic criteriaRecognition taskPANSS total scoreSensory modalitiesEmotion recognitionRecognition abilityEvaluation of symptomatologySeverity of clinical symptomsHappy prosodyNegative symptomsPerseveration errorsWAIS-IIIDSM-IVEmotional processingBrain systems
2007
No association evidence between schizophrenia and dystrobrevin-binding protein 1 (DTNBP1) in Taiwanese families
Liu C, Liu Y, Fann C, Yang W, Wu J, Hung S, Chen W, Chueh C, Liu W, Liu C, Hsieh M, Hwang T, Faraone S, Tsuang M, Hwu H. No association evidence between schizophrenia and dystrobrevin-binding protein 1 (DTNBP1) in Taiwanese families. Schizophrenia Research 2007, 93: 391-398. PMID: 17407805, DOI: 10.1016/j.schres.2007.02.003.Peer-Reviewed Original ResearchConceptsDystrobrevin-binding protein 1Single locusIntermarker linkage disequilibriumAssociation evidencePositional candidate genesHaplotype association analysisProtein 1Linkage disequilibriumCandidate genesLinkage studiesAssociation analysisHaplotype analysisFamily sampleGenesNo significant associationAffected siblingsEtiology of schizophreniaHaplotypesLociSiblings of schizophreniaTaiwanese familiesSignificant associationTransmit programsSchizophreniaAssociation