Perforin and Fas Ligand Are Required for the Regulation of Alloreactive CD8+ T Cells.
Maeda Y, Levy R, Reddy P, Liu C, Teshima T, Ferrara J. Perforin and Fas Ligand Are Required for the Regulation of Alloreactive CD8+ T Cells. Blood 2004, 104: 3052. DOI: 10.1182/blood.v104.11.3052.3052.Peer-Reviewed Original ResearchDonor T cellsT cellsDonor CD8WT T cellsAlloreactive CD8Day 10Day 30Host antigen presenting cellsFas ligandSingle MHC class IHost dendritic cellsModel of graftT cell populationsAntigen presenting cellsT cell homeostasisFas ligand pathwayMHC class IAllogeneic CD8Bm1 miceLethal GVHDSevere GVHDSignificant GVHDHost diseaseBMT recipientsEpithelial target cellsCCR1 Expression on Donor Leukocytes Is Critical to the Development of Graft Versus Host Disease after Allogeneic SCT.
Hildebrandt G, Choi S, Olkiewicz K, Chensue S, Liu C, Cooke K. CCR1 Expression on Donor Leukocytes Is Critical to the Development of Graft Versus Host Disease after Allogeneic SCT. Blood 2004, 104: 3067. DOI: 10.1182/blood.v104.11.3067.3067.Peer-Reviewed Original ResearchT cell responsesAllo-SCTCCR1 expressionDonor leukocytesHost diseaseT cellsCell responsesDonor T-cell responsesGraft Versus Host DiseaseAllogeneic stem cell transplantationSerum IFNγ levelsTranslocation of endotoxinVersus Host DiseaseDonor T cellsSeverity of GVHDDonor cellsClinical scoring systemStem cell transplantationT cell expansionAcute graftGVL effectSignificant GVHDTNFa levelsAllogeneic SCTClinical GVHD