2009
NOD2 regulates hematopoietic cell function during graft-versus-host disease
Penack O, Smith O, Cunningham-Bussel A, Liu X, Rao U, Yim N, Na I, Holland A, Ghosh A, Lu S, Jenq R, Liu C, Murphy G, Brandl K, van den Brink M. NOD2 regulates hematopoietic cell function during graft-versus-host disease. Journal Of Experimental Medicine 2009, 206: 2101-2110. PMID: 19737867, PMCID: PMC2757869, DOI: 10.1084/jem.20090623.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsNOD2 deficiencyHost diseaseCrohn's diseaseExperimental allogeneic bone marrow transplantationAllogeneic bone marrow transplantationHost antigen-presenting cellsAllo-BMT recipientsDevelopment of GVHDExperimental colitis modelHematopoietic cellsHost hematopoietic cellsDonor T cellsIndependent risk factorBone marrow chimerasBone marrow transplantationChimeric recipientsIntestinal inflammationProinflammatory stateColitis modelMarrow transplantationNOD2 mutationsRisk factorsT cellsPaneth cells
2004
Allo-Antigen Expression on Both APCS and Tumor Is Required To Elicit an Effective GVL Response after Experimental Allogeneic BMT.
Reddy P, Maeda Y, Liu C, Dinarello C, Ferrara J. Allo-Antigen Expression on Both APCS and Tumor Is Required To Elicit an Effective GVL Response after Experimental Allogeneic BMT. Blood 2004, 104: 595. DOI: 10.1182/blood.v104.11.595.595.Peer-Reviewed Original ResearchDonor T cellsAntigen presenting cellsT cellsAllogeneic BMTHost antigen presenting cellsLeukemia/tumor effectClass ITarget tissuesComplete donor chimerismBone marrow chimerasMinor H antigensPro-inflammatory cytokinesMalignant target cellsMHC class ICytokine blockadeGVL effectTCD BMGVH reactionGVL responseHistologic presenceDonor chimerismTumor effectSecond tumorImmunotherapeutic potentialSyngeneic controls
2003
Impaired thymic negative selection causes autoimmune graft-versus-host disease
Teshima T, Reddy P, Liu C, Williams D, Cooke K, Ferrara J. Impaired thymic negative selection causes autoimmune graft-versus-host disease. Blood 2003, 102: 429-435. PMID: 12663438, DOI: 10.1182/blood-2003-01-0266.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAutoimmune DiseasesBone Marrow TransplantationCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedClonal DeletionDendritic CellsEpithelial CellsFemaleGraft vs Host DiseaseInflammation MediatorsInterleukin-1MiceMice, Inbred C57BLRadiation ChimeraRadiation ToleranceSelf ToleranceSkinSpleenThymectomyThymus GlandT-Lymphocyte SubsetsTumor Necrosis Factor-alphaVisceraConceptsThymic negative selectionSystemic autoimmune diseaseAntigen-presenting cellsAutoimmune diseasesHost diseaseT cellsAutoreactive T cell repertoireClass IIThymic antigen-presenting cellsMajor histocompatibility complex class IIHistocompatibility complex class IIImpaired negative selectionLethal autoimmune diseaseBone marrow chimerasPeripheral regulatory mechanismsT cell repertoireMHC class IIMHC class INegative selectionAcute graftAcute GVHDAutoimmune graftPeripheral CD4Adoptive transferNaive mice
2002
Acute graft-versus-host disease does not require alloantigen expression on host epithelium
Teshima T, Ordemann R, Reddy P, Gagin S, Liu C, Cooke K, Ferrara J. Acute graft-versus-host disease does not require alloantigen expression on host epithelium. Nature Medicine 2002, 8: 575-581. PMID: 12042807, DOI: 10.1038/nm0602-575.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsHost antigen-presenting cellsAlloantigen expressionAcute GVHDHost diseaseTarget epitheliaMajor histocompatibility complex class ICD8-mediated GVHDBone marrow chimerasHistocompatibility complex class IClass II alloantigensTumor necrosis factorComplex class IAcute graftInflammatory cytokinesEffector mechanismsGVHDNecrosis factorMouse modelAntigen specificityTissue damageClass IHost epitheliumEpitheliumGraft