2024
Comparative Outcomes of Peripheral Vascular Interventions in Patients on Chronic Anticoagulation with Factor Xa Inhibitors and Vitamin K Antagonists
Huttler J, Alameddine D, Damara F, Rodriguez P, Wu Z, Slade M, Strosberg D, Ochoa Chaar C. Comparative Outcomes of Peripheral Vascular Interventions in Patients on Chronic Anticoagulation with Factor Xa Inhibitors and Vitamin K Antagonists. Annals Of Vascular Surgery 2024, 104: 185-195. PMID: 38493886, DOI: 10.1016/j.avsg.2023.12.092.Peer-Reviewed Original ResearchVitamin K antagonistsPeripheral arterial diseaseChronic anticoagulationLong-term outcomesFactor Xa inhibitorsAmputation-free survivalK antagonistsXa inhibitorsVitamin K antagonist groupMultivariate logistic regression analysisOutcomes of patientsKaplan-Meier analysisCox proportional hazards regressionLong-term followRate of hematomaProportional hazards regressionPeripheral vascular interventionsLogistic regression analysisOptimal regimenPatient demographicsAnticoagulation regimensVenous thromboembolismAtrial fibrillationFXaIProcedural characteristics
2019
Statin therapy associated with improved thrombus resolution in patients with deep vein thrombosis
Hsu C, Brahmandam A, Brownson KE, Huynh N, Reynolds J, Lee AI, Fares WH, Ochoa Chaar CI. Statin therapy associated with improved thrombus resolution in patients with deep vein thrombosis. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2019, 7: 169-175.e4. PMID: 30660579, DOI: 10.1016/j.jvsv.2018.10.020.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnticoagulantsElectronic Health RecordsFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedPlatelet Aggregation InhibitorsPulmonary EmbolismRecurrenceRetrospective StudiesRisk AssessmentRisk FactorsThrombolytic TherapyTime FactorsTreatment OutcomeVena Cava FiltersVenous ThromboembolismVenous ThrombosisConceptsDeep venous thrombosisExtent of DVTStatin therapyThrombus resolutionPulmonary embolismVenous thromboembolismVTE recurrenceAntiplatelet therapyMultivariable analysisRisk factorsRecurrence of DVTLower extremity deep venous thrombosisHigh-risk pulmonary embolismPrior deep venous thrombosisProvoked deep venous thrombosisProximal deep venous thrombosisInferior vena cava filter placementExtremity deep venous thrombosisVena cava filter placementDuration of anticoagulationAssociation of statinConsecutive adult patientsDirect oral anticoagulantsManifestations of atherosclerosisCava filter placement
2017
Systematic review of May-Thurner syndrome with emphasis on gender differences
Kaltenmeier CT, Erben Y, Indes J, Lee A, Dardik A, Sarac T, Ochoa Chaar CI. Systematic review of May-Thurner syndrome with emphasis on gender differences. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2017, 6: 399-407.e4. PMID: 29290600, DOI: 10.1016/j.jvsv.2017.11.006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMay-Thurner syndromeSystematic reviewLeg swellingPulmonary emboliEndovascular interventionIliac vein compression syndromeMore leg painDeep venous thrombosisEnglish literatureVein compression syndromeIliac vein compressionStudent's t-testAnatomic compressionCockett syndromeLeg painAsymptomatic patientsVenous thromboembolismComplication rateVenous thrombosisCompression syndromeEndovascular treatmentMale patientsVein compressionCase seriesMedical managementWhole-exome sequencing in evaluation of patients with venous thromboembolism
Lee EJ, Dykas DJ, Leavitt AD, Camire RM, Ebberink E, García de Frutos P, Gnanasambandan K, Gu SX, Huntington JA, Lentz SR, Mertens K, Parish CR, Rezaie AR, Sayeski PP, Cromwell C, Bar N, Halene S, Neparidze N, Parker TL, Burns AJ, Dumont A, Yao X, Chaar CIO, Connors JM, Bale AE, Lee AI. Whole-exome sequencing in evaluation of patients with venous thromboembolism. Blood Advances 2017, 1: 1224-1237. PMID: 29296762, PMCID: PMC5728544, DOI: 10.1182/bloodadvances.2017005249.Peer-Reviewed Original ResearchWhole-exome sequencingVenous thromboembolismStudy patientsThrombophilia panelVTE patientsHeritable thrombophiliaThrombophilia testingDisease-causing genetic variantsEvaluation of patientsControl patientsThrombophilia mutationsProtein modelingThrombotic historyProtein structurePatientsThrombophilia genesVTE pathogenesisWES variantsUnknown significanceThrombophiliaGenetic variantsGenesPrior reportsSequencingThromboembolism