1996
Function and expression of a human idiotypic network in Schistosomiasis japonica
WISNEWSKI A, OLDS G, JOHNSON J, RAMIREZ B, KRESINA T. Function and expression of a human idiotypic network in Schistosomiasis japonica. Parasite Immunology 1996, 18: 439-447. PMID: 9226679, DOI: 10.1111/j.1365-3024.1996.tb01027.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntibodies, Anti-IdiotypicAntibodies, HelminthAntibodies, HeterophileAntigens, HelminthChildFemaleGranulomaHumansImmunoglobulin GImmunoglobulin IdiotypesIn Vitro TechniquesLymphocyte ActivationMiceOvumPregnancySchistosoma japonicumSchistosomiasis japonicaSolubilityT-LymphocytesConceptsS. japonicum soluble egg antigensAnti-idiotypic antibodiesSchistosomiasis japonicaHuman anti-idiotypic antibodySoluble egg antigenNon-related antigensAnti-idiotypic antiseraS. japonicum infectionHuman lymphocyte blastogenesisCross-reactive idiotypeDose-dependent mannerHepatosplenic diseaseAcute infectionSerum levelsBlastogenic responseLymphocyte blastogenesisEgg antigenImmunoregulatory networkGranuloma formationJaponicum infectionFormation assaysS. japonicumAntibodiesAntigenDependent manner
1995
Induction of protective immunity to schistosomiasis with immunologically cross-reactive Lumbricus molecules
Wisnewski AV, Kresina TF. Induction of protective immunity to schistosomiasis with immunologically cross-reactive Lumbricus molecules. International Journal For Parasitology 1995, 25: 503-510. PMID: 7543459, DOI: 10.1016/0020-7519(94)00132-8.Peer-Reviewed Original ResearchConceptsVaccination of miceCandidate vaccine moleculesS. japonicum infectionS. japonicum paramyosinSchistosomiasis patients' seraMurine immune seraSchistosomiasis patientsProtective immunitySchistosome infectionPatient seraJaponicum infectionImmune serumUninfected individualsAntibody productionAntigen preparationsVaccine moleculesMultiple antigensRodent seraParasite moleculesMurine antibodyCross-reactive moleculesS. japonicumSerumAntigenSchistosoma japonicum
1992
Human Hybridoma Generation by Hypo-Osmolar Electrofusion: Characterization of Human Monoclonal Antibodies to Schistosoma mansoni Parasite Antigens
Klock G, Wisnewski AV, el-Bassiouni EA, Ramadan MI, Gessner P, Zimmermann U, Kresina TF. Human Hybridoma Generation by Hypo-Osmolar Electrofusion: Characterization of Human Monoclonal Antibodies to Schistosoma mansoni Parasite Antigens. Monoclonal Antibodies In Immunodiagnosis And Immunotherapy 1992, 11: 469-481. PMID: 1398684, DOI: 10.1089/hyb.1992.11.469.Peer-Reviewed Original ResearchConceptsHuman monoclonal antibodyMonoclonal antibodiesIgG antibodiesParasite antigensHypo-osmolar electrofusionS. mansoniSchistosoma mansoni wormsCell linesWestern blot analysisEgg antigenParasitic antigensAntigen reactivityAntigenAntibodiesSplenocytesBlot analysisHybridomasCandidate moleculesMansoniHybridoma generationMitogenCell fusionSomatic cell fusionGreater numberELISA
1991
Screening of murine monoclonal antibodies against living schistosomula of Schistosoma mansoni by radioimmunoassay
Wiest P, Wisnewski A, Johnson J, Ramirez B, Kresina T, Olds G. Screening of murine monoclonal antibodies against living schistosomula of Schistosoma mansoni by radioimmunoassay. International Journal For Parasitology 1991, 21: 449-454. PMID: 1917285, DOI: 10.1016/0020-7519(91)90102-d.Peer-Reviewed Original ResearchConceptsMurine monoclonal antibodiesSurface antigenSoluble adult worm antigenSchistosoma mansoniMonoclonal antibodiesS. mansoni paramyosinS. mansoni infectionSoluble egg antigenAdult worm antigenEnzyme-linked immunosorbentMansoni infectionEgg antigenLung stageWorm antigenS. mansoniSecrete antibodiesAntigenSchistosomulaAdult wormsAntibodiesRadioimmunoassayMansoniImmunoblot analysisOld parasitesMurine hybridomasAn immunoregulatory human monoclonal antibody in schistosomiasis japonica
Kresina T, Guan X, Posner M, Wisnewski A, Olds G. An immunoregulatory human monoclonal antibody in schistosomiasis japonica. Human Antibodies 1991, 2: 42-45. PMID: 1651785, DOI: 10.3233/hab-1991-2107.Peer-Reviewed Original ResearchConceptsHuman monoclonal antibodyMonoclonal antibodiesEgg antigenAntigen-induced blastogenesisAdult wormsEpstein-Barr virusSoluble egg antigenOS cell linesWestern blot analysisChronic schistosomiasisSoluble eggBarr virusChinese patientsChronic diseasesAntibody-producing hybridomasAntigen reactivitySchistosomiasis japonicaCarbohydrate antigensWestern blotDecompression operationMurine splenocytesSplenocytesAntibodiesAntigenSchistosoma japonicum