2024
Lung Gene Expression Suggests Roles for Interferon-Stimulated Genes and Adenosine Deaminase Acting against RNA‑1 in Pathologic Responses to Diisocyanate
Wisnewski A, Liu J. Lung Gene Expression Suggests Roles for Interferon-Stimulated Genes and Adenosine Deaminase Acting against RNA‑1 in Pathologic Responses to Diisocyanate. Chemical Research In Toxicology 2024, 37: 476-485. PMID: 38494904, DOI: 10.1021/acs.chemrestox.3c00325.Peer-Reviewed Original ResearchLung gene expressionNonsensitized miceImmune-sensitizationType I interferon-stimulated genesI interferon-stimulated genesAllergen-induced asthmaChemical-induced asthmaMolecular pathwaysADAR-1Ovalbumin-induced asthmaRegulation of innateInterferon-stimulated genesGene transcriptionGene expressionPathological responseAdenosine Deaminase ActingMurine modelAsthma-likeNonsensitized hostsLevels up to 10-foldLung tissueInnate responseLungTissue damageMice
2011
Vapor conjugation of toluene diisocyanate to specific lysines of human albumin
Hettick JM, Siegel PD, Green BJ, Liu J, Wisnewski AV. Vapor conjugation of toluene diisocyanate to specific lysines of human albumin. Analytical Biochemistry 2011, 421: 706-711. PMID: 22206939, PMCID: PMC3324820, DOI: 10.1016/j.ab.2011.12.013.Peer-Reviewed Original Research
2000
Identification of Human Lung and Skin Proteins Conjugated with Hexamethylene DiisocyanateIn Vitro and In Vivo
WISNEWSKI A, SRIVASTAVA R, HERICK C, XU L, LEMUS R, CAIN H, MAGOSKI N, KAROL M, BOTTOMLY K, REDLICH C. Identification of Human Lung and Skin Proteins Conjugated with Hexamethylene DiisocyanateIn Vitro and In Vivo. American Journal Of Respiratory And Critical Care Medicine 2000, 162: 2330-2336. PMID: 11112159, DOI: 10.1164/ajrccm.162.6.2002086.Peer-Reviewed Original ResearchConceptsDiisocyanate-induced asthmaBiopsy samplesHuman lungHuman airway epithelial cellsBronchoalveolar lavage fluidAirway epithelial cellsEndobronchial biopsy samplesHuman skin biopsy samplesSkin biopsy samplesKeratin 18Epicutaneous exposureLavage fluidSkin proteinsVivo inhalationVivo exposureEpithelial cell proteinsGlucose-regulated proteinEpithelial cellsAsthmaLungExposureVitroVivoKeratinCell proteins