Pancreas, Phase II
Phase II Study to Evaluate Modified Folfirinox and Stereotactic Body Radiation Therapy in Non-metastatic Unresectable Pancreatic Adenocarcinoma
Volunteers
Health Professionals
What is the purpose of this trial?
The purpose of this study is to evaluate the efficacy of modified FOLFIRINOX followed by stereotactic body radiotherapy (SBRT) in patients with borderline resectable pancreatic cancer (BRPC) and locally advanced pancreatic cancer (LAPC). The primary hypothesis will be to determine if modified FOLFIRINOX followed by SBRT improves progression free survival (PFS) compared to historical controls treated with gemcitabine-based chemotherapy with or without standard fractionated radiation.
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Principal Investigator
Sub-Investigators
- Agatha Hecht
- Andrea Brennan
- Armand Russo, MD
- Ashita Talsania, MRCP, MBBS
- Benjamin Newton, MD
- Brooke Chaves
- David Witt, MD
- Elan Gorshein, DO, JD, MPH
- Elizabeth Cappiello
- Harold Tara Jr, MD
- Harry Aslanian, MD
- Henry S. Park, MD, MPH
- Jacquelyne Gaddy, MD, MSc, MSCR
- Jade Vanacore
- James Farrell, MBChB
- James Vredenburgh, MD
- Jane Kanowitz, MD
- Jason Haldas, MD
- Jeremy Kortmansky, MD
- Jill Lacy, MD
- Johanna LaSala, MD
- Jose Morales-Marin
- Justin Persico, MD
- Katherine Harvey, MD, MPH
- Kert Sabbath, MD, FACP
- Kevin Du, MD, PhD, MSCI
- Kristen Hoxie
- Laura Sabourin
- Madeline Santiago
- Michael Cecchini, MD
- Michael Cohenuram, MD
- Michael Grant, MD
- Neal Fischbach, MD
- Pamela L. Kunz, MD
- Pawan Karanam, MD
- Robert Legare, MD
- Samantha Couillard
- Sara Anastasio, RN
- Sarah Carlson
- Sharynn Hall, MD, PhD
- Stacey Stein, MD
- Stephen Lattanzi, MD
- Su Hsien Lim, MD
- Sudhanshu Mulay, MD
- Teresa White
- Victor Chang, MD
- Vidya Kesavan
- Virginia Syombathy
- Xuanthao Thi Nguyen
- Yifei Zhang, MD
- Zia Rahman, MD
- Last Updated08/11/2023
- Study HIC#2000024671