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Examining the Effect of Burosumab on Muscle Function


Diseases of the Musculoskeletal System


What is the purpose of this trial?

Patients with X-linked hypophosphatemia (XLH) often report symptoms of fatigue and weakness particularly after exertion, in addition to their skeletal complaints. In previous trials using KRN23 (same drug as burosumab/Crysvita®), patients report these symptoms improve. The investigators wish to test this hypothesis directly by measuring muscle energy when patients begin treatment with Crysvita® for the first time.

  • Trial with
    Yale University School of Medicine
  • Start Date
  • End Date

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  • Study HIC