A Phase III, Randomized Study of Nivolumab (Opdivo) Plus AVD or Brentuximab Vedotin (Adcetris) Plus AVD in Patients (Age >/= 12 Years) With Newly Diagnosed Advanced Stage Classical Hodgkin Lymphoma
Conditions
Hodgkin's Lymphoma
Phase III
Volunteers
Health Professionals
What is the purpose of this trial?
This randomized phase III trial compares immunotherapy drugs (nivolumab or brentuximab vedotin) when given with combination chemotherapy in treating patients with newly diagnosed stage III or IV classic Hodgkin lymphoma. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Brentuximab vedotin is a monoclonal antibody, brentuximab, linked to a toxic agent called vedotin. Brentuximab attaches to cancer cells in a targeted way and delivers vedotin to kill them. Drugs used in chemotherapy, such as doxorubicin, vinblastine, and dacarbazine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The addition of nivolumab or brentuximab vedotin to combination chemotherapy may shrink the cancer or extend the time without disease symptoms coming back.
- Trial withSouthwest Oncology Group (SWOG)
- Start Date03/21/2022
- End Date03/01/2024
I'm interested in volunteering
If you would prefer to contact a member of the Help us Discover team about this trial and other similar trials, please email helpusdiscover@yale.edu or call 877.978.8343
Principal Investigator
Sub-Investigators
- Adam Boruchov, MD
- Agatha Hecht
- Alexis Walker
- Andrea Brennan
- Andrea Martelli
- Armand Russo, MD
- Benjamin Newton, MD
- Beverly Drucker, MD, PhD
- Claudia Auerbach, APRN
- David Witt, MD
- Elan Gorshein, DO, JD, MPH
- Farzana Pashankar, MD, MRCP
- Francesca Montanari, MD
- Francine Foss, MD
- Harold Tara Jr, MD
- Iris Isufi, MD
- James Vredenburgh, MD
- Jane Kanowitz, MD
- Jason Haldas, MD
- Jaykumar Thumar, MBBS, MD
- Jeremy Kortmansky, MD
- Johanna LaSala, MD
- Juan Vasquez, MD
- Julie Baker
- Justin Persico, MD
- Kaitlin Brown
- Karishma Mehra, MBBS
- Kathleen Fenn, MD
- Kelsey Martin, MD
- Khanh Nguyen, MD
- Kristen Hoxie
- M. Sung Lee, MD
- Madeline Santiago
- Michael Cohenuram, MD
- Neal Fischbach, MD
- Pawan Karanam, MD
- Prasanna Ananth, MD, MPH
- Rebecca Cheron, APRN
- Robert Legare, MD
- Sara Anastasio, RN
- Sarah Carlson
- Shalin Kothari, MD
- Stephanie Massaro, MD, MPH
- Stephen Lattanzi, MD
- Stuart Seropian, MD
- Su Hsien Lim, MD
- Sudhanshu Mulay, MD
- Syed Bilgrami, MBBS
- Tarsheen Sethi, MD, MSCI
- Virginia Syombathy
- Wajih Kidwai, MD, FACP
- Last Updated03/23/2022
- Study HIC#2000026357