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Guanfacine to Improve Substance Use Outcomes in Women


Addictive Behaviors | Mental Health & Behavioral Research

Phase II

What is the purpose of this trial?

Detailed Description:

This study proposes to extend previous Phase I experimental work to address the following specific aims: (1) assess GUA's target engagement of drug craving and cognitive flexibility in a laboratory challenge session and in a 10-week outpatient clinical study, (2) demonstrate target validation by showing that reduced drug craving and improved cognitive flexibility will predict lower drug use outcomes during the 10-week clinical trial in SUD women, and finally, (3) evaluate data replication and scalability of GUA target effects across two clinical sites (Yale and SUNY-Stony Brook).

  • Trial with
    National Institute on Drug Abuse (NIDA)
  • Start Date
  • End Date

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  • Last Updated
  • Study HIC