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Genetic Determinants of Aneurysms in Autosomal Dominant Polycystic Kidney Disease

Conditions

Diseases of the Cardiovascular System | Diseases of the Kidney & Urinary Tract | Genetics - Adult

What is the purpose of this trial?

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease and results in kidney failure from accumulation of fluid-filled cysts in the kidney. Families with ADPKD are also at higher risk for intracranial aneurysm (ICA), for reasons that are unknown. This risk runs in families. Our study aims to identify genetic similarities amongst those ADPKD families who also have intracranial aneurysms (ICA) in contrast to those don’t develop ICA. We are recruiting ADPKD patients who have had past or recent brain imaging that showed (or excluded) ICA.

Participants must be 18 years of age. Participation requires a one-time blood sample for research genetic testing of DNA using whole exome sequencing.

  • Trial with
    Department of the Army
  • Start Date
    01/05/2021
  • End Date
    12/31/2022

I'm interested in volunteering

If you would prefer to contact a member of the Help us Discover team about this trial and other similar trials, please email helpusdiscover@yale.edu or call 877.978.8343

  • Last Updated
    07/15/2021
  • Study HIC
    #2000029350