A Phase III Double-Blind Trial for Surgically Resected Early Stage Non-small Cell Lung Cancer: Crizotinib Versus Placebo for Patients With Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein
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What is the purpose of this trial?
This randomized phase III trial studies how well crizotinib works and compares it to placebo in treating patients with stage IB-IIIA non-small cell lung cancer that has been removed by surgery and has a mutation in a protein called anaplastic lymphoma kinase (ALK). Mutations, or changes, in ALK can make it very active and important for tumor cell growth and progression. Crizotinib may stop the growth of tumor cells by blocking the ALK protein from working. Crizotinib may be an effective treatment for patients with non-small cell lung cancer and an ALK fusion mutation.
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Principal Investigator
Sub-Investigators
- Agatha Hecht
- Alessia Donadio, MD
- Alison Johnson
- Andrea Silber, MD
- Anne Chiang, MD, PhD
- Benjamin Newton, MD
- Beverly Drucker, MD, PhD
- Brooke Chaves
- Chelsea Semrau
- D. Barry Boyd, MD, MS
- David Witt, MD
- Emily Collier, MD
- Emily Duffield, APRN
- Erin Medoff
- Frederick Wilson, MD, PhD
- Harold Tara Jr, MD
- Jade Vanacore
- James Vredenburgh, MD
- Jane Kanowitz, MD
- Jason Haldas, MD
- Jeremy Kortmansky, MD
- Johanna LaSala, MD
- Justin Persico, MD
- Karishma Mehra, MBBS
- Katherine Harvey, MD, MPH
- Kathleen Fenn, MD
- Kert Sabbath, MD, FACP
- Kristen Hoxie
- Larisa Fleysher
- M. Sung Lee, MD
- Madeline Santiago
- Marianne Davies, NP, DNP, MSN, BSN
- Neal Fischbach, MD
- Pawan Karanam, MD
- Renee Moye
- Roy S. Herbst, MD, PhD
- Sarah Goldberg, MD, MPH
- Sarah Thomen, APRN
- Scott Gettinger, MD
- Su Hsien Lim, MD
- Sudhanshu Mulay, MD
- Vanna Dest
- Victor Chang, MD
- Vidya Kesavan
- Virginia Syombathy
- Wajih Kidwai, MD, FACP
- Xuanthao Thi Nguyen
- Zia Rahman, MD
- Last Updated02/01/2024
- Study HIC#1507016131