The PhenoGenetic Project

The aim of this project is to determine the role of genetic variation in the diversity of human immune response by testing DNA polymorphisms for association with immunological phenotypes in individuals with no clinical evidence of inflammatory or infectious diseases. In the subject population of this study, immunophenotypes will be characterized from serum and from peripheral blood mononuclear cells (PBMCs). Cytometric, RNA profiling and proteomic platforms will be used in these serological and cellular analyses. This study will genetically dissect human immune gene expression in a cohort of individuals with no clinical evidence of disease, yielding a wealth of data with which to guide the investigation of inflammatory and infectious diseases.