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Spotlight on Clinical Research: Asthma

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The Yale Center for Asthma and Airway Disease (YCAAD) provides world class medical treatment to adults and teens with difficult to control asthma and has one of the most active clinical trial programs in the Northeast for asthma.

The Center is  actively recruiting subjects for a number of clinical trials of novel biologics, or antibody-based drugs, to treat patients with severe asthma. These experimental medications bind to and block molecular targets in a pathway that drives the inflammation that occurs in asthmatic airways. 

“The early stage trials have been very promising and really suggest that when you target a molecule, rather than giving broad-based anti-inflammatory therapy, you can obliterate the inflammatory response that is behind the symptoms that patients with asthma have,” said Dr. Geoffrey Chupp, director of YCAAD. “It’s very exciting.” One biologic that was already tested at Yale and other sites around the country is expected to be approved by the FDA within about a year.

Patients with severe asthma may be eligible for these studies, in which the experimental drugs will be given, in addition to standard therapy. This includes those who are not able to adequately control their disease with standard inhaled therapies such as bronchodilators and inhaled steroids and those who have frequent flares or continuously have symptoms that require oral corticosteroids. The studies typically involve monthly injections for six to 12 months, plus follow-up visits for a period of time. Patients are closely followed by the outstanding team at YCAAD throughout the process.

In another study, the sputum and blood from asthma patients is being collected to analyze its genetic information and how genes function and interact. The goal is to understand asthma at the molecular level in order to identify patients with similar genetic profiles so that improved therapies can be developed and tested.

To find out if you’re eligible for an asthma clinical trial, contact YCAAD at 203-737-6174 or click here. For more information about YCAAD, visit http://asthma.yale.edu/index.aspx