YCCI Podcasts

Faculty associated with the Yale Center for Clinical Investigation discuss their efforts to put knowledge to work for patients. They recount stories of research that helps obese children achieve a healthy body weight, addresses the root causes of cardiovascular disease in African Americans and offers the parents of autistic children proven strategies to help their children – in other words, research with real-life benefits.

The Director's Perspective

YCCI's Directors speak about how the NIH Clinical and Translational Science Award is helping to transform clinical and translational research at Yale.

Dr. Robert Sherwin draws upon his career doing landmark research in diabetes to help new investigators pursue science that improves health care. Reflecting on his role as primary investigator of Yale’s CTSA, he sees a need to educate “translators,” researchers who can connect basic scientists and clinicians.

The Yale Center for Clinical Investigation fast-tracks research to help patients.

Yale Institutional Commitment

Leaders from across the medical campus discuss how the integration of the schools, medical practice and hospital is helping shape Yale's vision of clinical and translational research.

Yale School of Medicine Dean Robert Alpern talks about the university’s strides in fostering clinical and translational research, the role NIH funding has played in that progress, and his vision to bring still more knowledge to bear on patient care.

Dean of Public Health Paul Cleary talks about how YCCI has helped faculty to form true partnerships with New Haven neighborhoods. These efforts help place research into the hands of residents and advocates who can use it to build a healthier community.

Dean Margaret Grey describes the Yale School of Nursing’s long and deep history of community engagement. YSN’s strength in the community has helped set the direction for Yale’s CTSA. Yale nurses have also served as a resource to other CTSA sites nationally.

Dr. David Leffell describes the Yale system’s investment in an electronic health record. While protecting patient privacy, the EHR will be step one in a process to make data readily available for researchers.

Dr. Peter Herbert, chief medical officer at Yale-New Haven Hospital, talks about how the hospital and university are collaborating to attract top notch clinical and translational researchers and provide them with the resources they need to advance discovery.

Interview with Robert Alpern, MD, Dean of the Yale School of Medicine. We will talk with him about the School's accomplishments during his first term as Dean, and what he hopes to achieve during his second year.

Yale's Dean of Nursing talks about using science to rapidly benefit patients.

Robert J. Alpern, M.D., Dean of Yale School of Medicine and Ensign Professor of Medicine, explains how the school is uniquely positioned to lead the revolution in biomedical science in research, clinical care, and education.

Paul Cleary, Dean of the School of Public Health, C-EA Winslow Professor of Epidemiology & Public Health, talks about major issues affecting public health.

Yale School of Public Health aims to make a difference in New Haven.

Education and Career Development

YCCI's educational programs are helping train the next generation of clinical and translational research. Scholars in the Junior Faculty Scholars program are using their awards to advance their careers and leverage funding for their research.

Dr. Erik Shapiro is working to manipulate dormant stem cells to migrate to sites of injury or disease so that the body can effect its own repairs. He terms this out-of-the-box approach “high risk/high reward” science.

Dr. Tene Lewis has found that African-Americans who report a high rate of slights and mistreatments also show metabolic indicators that they are at risk for cardiovascular disease. Her future work will look at coping skills to help people avoid the dangerous health effects of discrimination, while also probing ways to reduce that discrimination.

In work he began as a YCCI Scholar, Dr. Peter Morgan found that men who recently stopped using cocaine don’t get enough sleep but are often unaware of it. Finding a suitable sleep aid for recovering addicts may help them continue to stay clean.

The Yale Center for Clinical Investigation teaches young scientists how to tailor their research to promote better health.

When Physicians Become Researchers, Patients Benefit.

Biomedical Informatics

Managing and analyzing large amounts of data is opening avenues for investigators to develop innovative new treatments.

Dr. Geoffrey Chupp discusses how he has used Yale’s informatics resources to identify a biomarker associated with severe asthma, a disease where current treatments only address symptoms. Dr. Chupp’s discovery creates the possibility of treating the root cause in this form of asthma. In the shorter term, it allows doctors to screen patients who may need more aggressive treatment.

Development of Novel Clinical and Translational Methodologies

YCCI's investment in core technologies is paving the way for cutting-edge research that is helping researchers understand the underpinnings of many diseases and may lead to new ways of treating them.

Yale’s high-throughput DNA sequencing capabilities allowed Dr. Richard Lifton to make the world’s first diagnosis using DNA alone. He discusses Yale’s investment in genomics and the promise it holds for translational research and clinical care.

Pilot Funding

Pilot funding is providing opportunities for Yale investigators to conduct promising research studies that capitalize on Yale expertise.

It’s not surprising that mothers who abuse cocaine are less attentive to their children. But learning the neural mechanisms behind their responses may lead to interventions that could help them parent better and even stop using the drug. Dr. Linda Mayes is conducting a multi-site brain imaging study with that goal in mind.

Like most drugs, cocaine has pleasurable and uncomfortable effects. Dr. Robert Malison studies how the drug produces these effects in the human brain. This knowledge could lead to new addiction treatments that would make the experience of using cocaine less enticing.

Regulatory Knowledge

YCCI is finding ways to break down barriers that stand in the way of conducting clinical research and working with other CTSA institutions to share lessons learned and develop best practices.

Dr. Sandra Alfano talks about how she’s working with other institutions to improve the way Institutional Review Boards – independent committees that ensure the protection of participants in clinical trials -- work. Institutions that have received CTSA funding from the NIH are sharing best practices in the complex process of approving research studies.

Tesheia Johnson talks about collaboration among institutions ramping up clinical and translational science. CTSA institutions share best practices as administrators and researchers reach out to colleagues at other consortium schools.

Dr. William Tamborlane’s groundbreaking research changed the way diabetes is managed, but he says that research of that kind is becoming increasingly difficult to do. In his roles at YCCI and the ORS, Dr. Tamborlane works to remove barriers for the next generation of clinical researchers.

Yale Cancer Center's new director vows to fast-track research.

Sandra Alfano's job is to protect the rights of volunteers in clinical research.

Clinical Research Resources

YCCI's clinical research resources include a convenient outpatient facility and an inpatient unit at Yale-New Haven Hospital with a skilled nursing staff and state-of-the-art equipment to support complex clinical research studies.

The littlest volunteers: why we do medical research with children.

Program helps obese children lose weight through unique approach.

Steven Marans, Director of the National Center for Children Exposed to Violence a tthe Yale Child Study Center, discusses children's fears, ranging from bedtime anxiety to the threat of real violence in their lives.

Dr. Charles Lockwood gives an overview of the many recent research and clinical advances by researchers in Yale Ob/Gyn.

Janine Evans, M.D., describes clinical research processes, using the development of the Lyme Disease vaccine as an example. She also discusses the 1994-97 human clinical trials for the Lyme vaccine at the Yale School of Medicine.

Jane Metzger, DNSc, RN, delivers the Bellos Lecture at Yale School of Nursing. Her talk discusses rapidly changing forces in health care and their impact on the profession of nursing.

Lawrence Scahill, Professor, Yale School of Nursing, Associate Professor, Yale Child Study Center, discusses the symptoms and treatment of Tourette Syndrome.

Biostatistics and Study Design

A joint effort between YCCI and the School of Public Health, the Yale Center for Analytical Sciences expands on the biostatistical support offered by YCCI to assist investigators in this important aspect of clinical and translational research.

Health economist, Peter Peduzzi, demystifies research methods and at the same time works to develop more powerful and sophisticated tools to harness vast amounts of data.

Biostatistician James Dziura talks about his work on a study that revealed effective ways for parents to help their children with autism. Professor Dziura is a frequent collaborator with a wide variety of researchers as manager of YCCI’s biostatistical support.

Community-Based Research, Education and Engagement

YCCI is training investigators in community-based participatory research and forming partnerships with community organizations and health care providers to design and conduct research that addresses the health concerns of the surrounding community.

The Robert Wood Johnson Clinical Scholars Program prepares young physicians to make broad, systemic changes in health care. Director Harlan Krumholz describes the unique approach to leadership training in the program as well as its strong emphasis on community-based participatory research.

Georgina Lucas, discusses community-based participatory research. This model, where the university and community enjoy true partnership, spawned a system to fill the gap in specialty care for low-income patients.

Robert Wood Johnson Clinical Scholars prepare to be change agents in health care.

Yale initiative aims to make New Haven a healthier place.

Margaret Grey, Dean of Yale School of Nursing and Annie Goodrich Professor of Nursing, talks about how her research helps children with diabetes live healthier lives.

Evaluation and National Program Benefit

YCCI is continuously evaluating its performance and progress and is actively involved in sharing best practices with other CTSA sites in order to enhance and facilitate clinical and translational research.