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COVID-19 Vaccine, Phase COVID-NA

COVID-19 Booster Vaccine in Autoimmune Disease Non-Responders

What is the purpose of this trial?

This is a randomized, multi-site, adaptive, open-label clinical trial comparing the immune response to different COVID-19 vaccine booster doses in participants with autoimmune disease requiring immunosuppressive medications. All study participants will have negative serologic or sub-optimal responses (defined as a Roche Elecsys® Anti-SARS-CoV-2 S (RBD) result ≤ 50 U/mL) to initial COVID-19 vaccine regimen with Moderna COVID-19 vaccine, Pfizer-BioNTech COVID-19 vaccine, or Janssen COVID-19 vaccine.

The study will initially focus on 5 autoimmune diseases:

  • Systemic Lupus Erythematosus (SLE)
  • Rheumatoid Arthritis (RA)
  • Multiple Sclerosis (MS)
  • Systemic Sclerosis (SSc), and
  • Pemphigus.

Contact Information

For more information about this study, including how to volunteer, contact Julie Heffernan

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