Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS)
Diseases of the Blood | Infectious Diseases
What is the purpose of this trial?
Multicenter, prospective, phase 3 randomized non-blinded interventional trial of fluid treatment strategies in the first 24 hours for patients with sepsis-induced hypotension. The aim of the study is to determine the impact of a restrictive fluids strategy (vasopressors first followed by rescue fluids) as compared to a liberal fluid strategy (fluids first followed by rescue vasopressors) on 90-day in-hospital mortality in patients with sepsis-induced hypotension.
- Ages18 years and older
- Trial withNational Heart, Lung, and Blood Institute (NHLBI)
- Start Date11/04/2018
- End Date03/29/2021
- Last Updated02/22/2019
- Study HIC#2000023369