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Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS)

Conditions

Diseases of the Blood | Infectious Diseases

Phase III

What is the purpose of this trial?

Brief Summary:

Multicenter, prospective, phase 3 randomized non-blinded interventional trial of fluid treatment strategies in the first 24 hours for patients with sepsis-induced hypotension. The aim of the study is to determine the impact of a restrictive fluids strategy (vasopressors first followed by rescue fluids) as compared to a liberal fluid strategy (fluids first followed by rescue vasopressors) on 90-day in-hospital mortality in patients with sepsis-induced hypotension.

  • Trial with
    National Heart, Lung, and Blood Institute (NHLBI)
  • Start Date
    11/04/2018
  • End Date
    03/29/2021
Trial Image

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  • Last Updated
    02/22/2019
  • Study HIC
    #2000023369