Intravenous (IV) Nicotine Self Administration: Dose Ranging and Sex Differences in Smokers

Conditions

Addictive Behaviors | Tobacco Addiction

What is the purpose of this trial?

The proposed study will examine the threshold for nicotine self-administration using four different nicotine doses in young adult male and female smokers with-or-without nicotine dependence (light and intermittent smokers or LITS).

Aim #1: To further characterize the reinforcing threshold and dose-response curve for IV nicotine self-administration in male and female smokers with or without nicotine dependence. The reinforcing effects of nicotine will be determined by the number of IV nicotine self-administrations.

Hypothesis 1a) female smokers, compared to males, will have a lower threshold and a steeper slope for nicotine reinforcement, indicating greater sensitivity to nicotine.

Hypothesis 1b) non-dependent smokers, compared to dependent smokers, will have a lower threshold and a steeper slope for nicotine reinforcement.

Aim#2: To further characterize the threshold and dose-response curve for the subjective-rewarding effects of self-administered IV nicotine in male and female smokers with or without nicotine dependence. The subjective-rewarding effects of nicotine will be determined by the "good effects" and "drug liking" items of the Drug Effects Questionnaire.

Hypothesis 2a) female smokers, compared to males, will have a lower threshold and a steeper slope for the subjective-rewarding effects of nicotine.

Hypothesis 2b) non-dependent smokers, compared to dependent smokers, will have a lower threshold and a steeper slope for the subjective-rewarding effects of nicotine, indicating greater sensitivity to nicotine.

  • Trial with
    National Institute on Drug Abuse (NIDA)
  • Start Date
    04/06/2011
  • End Date
    10/30/2015

I'm interested in volunteering

If you would prefer to contact a member of the Help us Discover team about this trial and other similar trials, please email helpusdiscover@yale.edu or call 877.978.8348

Trial Image

For more information about this study, contact:

Stacy Minnix

  • Last Updated
    06/22/2018
  • Study HIC
    #1010007514