Yale Launches Comprehensive DNA Sequencing Project, With Aim of Predicting, Preventing, and Treating Gene-related Diseases
Generations, a collaboration between Yale School of Medicine and Yale New Haven Health System, is one of the largest DNA sequencing projects of its kind in the United States.
Yale scientists study genes misidentified as ‘non-protein coding’
The human genome contains regions that “code” for proteins, which means they have instructions to make protein molecules with specific functions in the body. But Yale researchers have discovered several protein-coding genes that were misidentified as non-protein-coding, and one in particular that plays a key role in the immune system.
Yale study: Mapping tumors’ genes doesn’t improve survival
In this age of personalized medicine, sequencing the genes in a patient’s tumor can reveal mutations that may be treatable with targeted medications. But a new Yale School of Medicine-led study published Aug. 7 in the Journal of the American Medical Association shows that testing for many such mutations does not improve the chances of a patient’s survival. Data was analyzed from 5,688 patients with non-small cell lung cancer who were treated in a community cancer clinic rather than a large research institution. About 15 percent received broad-based sequencing of the tumor’s genome; the rest were tested only for two mutations, known as EGFR and ALK, for which medications are available. Incorporating variables into the analysis, the researchers found that mortality rates after 12 months were 41.1 percent for those who had the broad-based sequencing and 44.4 percent for those who just had the tests for EGFR and ALK.
Genome screen uncovers new targets for cancer immunotherapy
A new genome-wide screen of 20,000 human genes in T cells have turned up several new candidates to unleash the immune system’s ability to attack a variety of tumor types, Yale Cancer Center researchers report Aug. 22 in the journal Cell.
Genetically Sequencing DNA Could Yield Patient Care Insights
Yale Medicine and Yale New Haven Health, along with several other institutions across the country, are beginning to offer whole-exome sequencing as part of very large studies designed to discover more information about the role of genes, and gene variants, in disease.
Newly Funded Chromatin Study Could Shed Light on Genome
Combining engineering, biology and physics, three Yale researchers have received a four-year grant from the National Science Foundation (NSF) to study chromatin in yeast cells. They aim to better understand chromatin's properties and use the genome as a device to measure and record dynamic, transient chromatin states.
Would Routine Genomic Testing For Cancer And Heart Risk Make Economic Sense?
If all adults were to have their genes sequenced during their annual physicals this year, the vast majority of us would not learn anything that would change our medical routines going forward. But an estimated 1% of Americans—at least 3 million people—would find genetic abnormalities that greatly raise their risk of cancer or heart disease. And that, says Yale School of Medicine genetics expert Michael Murray, would make all of that testing worth it, not only to those individuals, but to society as a whole. Even if each person had just 10 genes tested, the benefits would outweigh the costs, argues Murray, who wrote an article published today in the journal Annals of Internal Medicine that urges health systems to embrace routine genomic testing. That’s because such testing would reveal “actionable” gene mutations—well-known risks for diseases that can be avoided with specific screening or prevention methods.
Michael F. Murray joins Center for Genomic Health
Yale New Haven Hospital and Yale School of Medicine (YSM) today jointly announced the appointment of Michael F. Murray, MD to become the director of Clinical Operations for Yale School of Medicine and Yale New Haven Hospital’s Center for Genomic Health.
Genetic Underpinnings of AMD, Other Diseases Revealed in YSPH Studies
A Yale School of Public Health researcher who discovered the gene behind age-related macular degeneration (AMD) has made new discoveries that increase the understanding of the mechanisms behind AMD and other diseases, including Parkinson’s disease.
In heavy drinkers, expression of gene predicts stress-induced alcohol consumption
Yale researchers have uncovered a set of genes that are expressed in stressed heavy drinkers that do not become activated in moderate drinkers. The new data, published in the journal Alcoholism: Clinical and Experimental Research, suggests a mechanism by which psychological stress triggers alcohol consumption in heavy drinkers.
Gene implicated in 'tanning dependence'
A team led by researchers at the Yale School of Public Health say they have found a gene associated with UV "tanning dependence", which has been characterized as a behavioral disorder. A study published Dec. 1 in Experimental Dermatology identified the gene through scanning the exomes of 79 people with symptoms of tanning dependency and 213 people who did not show dependency symptoms.
Breakthrough discovery opens new avenues for blocking transmission of African sleeping sickness
Scientists at the Yale School of Public Health and Yale School of Medicine have for the first time replicated in a laboratory setting the process of becoming infectious that occurs in the parasite that causes trypanosomiasis, more commonly known as African sleeping sickness.
The Genetics of Health - A School of Public Health researcher studies the human genome to find the origins of common diseases.
Andrew T. DeWan studies the human genome and how genetic abnormalities contribute to specific diseases. He is currently seeking to identify genes that are a factor in pregnancy-related complications such as preeclampsia and early childhood diseases such as asthma.