New Research May Explain Unexpected Effects of Common Painkillers
Some NSAIDs prevent heart disease while others cause it; some NSAIDs have been linked to decreased incidence of colorectal cancer; and various NSAIDs can have a wide range of effects on asthma. Now, using cell cultures and mice, Yale researchers have uncovered a distinct mechanism by which a subset of NSAIDs reduce inflammation. And that mechanism may help explain some of these curious effects.Source: YaleNews
Discovering a Mysterious Estrogen’s Important Role in Pregnancy
When a woman becomes pregnant, her levels of estriol, one of the three common estrogens that are nearly undetectable before conception, skyrocket. However, scientists never knew what this hormone does or why levels of it build as they do. Now, Yale researchers have discovered that estriol plays an extremely important role in shaping the future of offspring.
Four Yale Researchers Honored at the 2022 Association for Clinical and Translational Science Awards
The collaboration that advanced the discovery of ketamine as a treatment for depression was among four Yale award winners at the Association for Clinical and Translational Science (ACTS) annual meeting held in Chicago from April 20 through 22.
How Effects on the Brain Can Produce Long COVID
COVID-19 may be primarily a respiratory illness, but its reach extends far beyond the lungs, with an impact that includes the brain. The neurologic and psychiatric complications of COVID-19 are incredibly diverse and sometimes persist long after patients recover from their initial infections.
Racial Disparities in COVID-19 Death Rates Diminished in Connecticut
In the United States, COVID-19 has disproportionately affected Black and Hispanic populations, with those groups experiencing higher COVID-19-related death rates than non-Hispanic white Americans. But a new Yale-led analysis of these disparities in Connecticut found that they have decreased over the course of the pandemic, with mortality rate disparities narrowing substantially by the end of 2021.Source: YaleNews
Yale Findings Broaden the Repertoire of Cancer-relevant Genes
Following an analysis of over 12,000 human genes, research from Yale Cancer Center indicates there is cancer-relevant importance in a much larger proportion of human genes than current cancer research models suggest. Much of cancer biology research focuses on a few dozen well studied genes called “cancer driver genes.” The new findings demonstrate that a larger number of genes are connected to cancer driver genes and may have an impact on cancer biology. The findings were published in the Journal of the National Cancer Institute.
Moving Forward for the Health of Women: A Conversation with Dean Nancy J. Brown
Yale School of Medicine Dean Brown and Women's Health Research at Yale Director Carolyn M. Mazure, PhD, speak about the importance of research, the value of a focus on studying women, the influence of biology and social factors that differentially affect the health of women and men, community outreach, diversity, equity, and more.
New Study by Yale’s Center for Methods in Implementation and Prevention Science’s Director, Donna Spiegelman, Finds High Long-Term Survival from Common Cancers After Surviving the First 5 Years
Dr. Donna Spiegelman, Director of Yale’s Center for Methods in Implementation and Prevention Science, her recent Ph.D. student, Dr. En Cheng, and other colleagues from Yale University, Kaiser Permanente of Northern California, Harvard University, and Weill Cornell investigated long-term survival after diagnosis from common cancers.
HIV Hides Within Immune System’s ‘Police Stations’
HIV hides within specialized cells known as cytotoxic CD4+ T cells, which are the immune system’s best fighters, a new study by Yale School of Medicine researchers found. These HIV-infected immune cells are able to shield themselves from being destroyed by other immune system cells.Source: YaleNews
Insights & Outcomes: T cells, drinking risks, and COVID-19’s road ahead
Kidney clues Although immunotherapy has significantly increased survival rates of patients with several types of cancer, some underlying conditions such as acute kidney injury (AKI) can increase risk of death among people receiving treatment with therapies such as immune checkpoint inhibitors. However, researchers at the Yale School of Medicine have found that in a subset of cancer patients, the AKI diagnosis may not be bad news at all, but rather an indication immunotherapy is working.Source: Yale New: Research Roundup
Ariadna Forray, MD and Kim Blenman, PhD, MS Take the Helm at MORE
The new co-directors of Minority Organization for Expansion and Retention (MORE), Ariadna Forray, MD, associate professor of psychiatry, and Kim Blenman, PhD, MS, assistant professor of medicine (medical oncology) and assistant professor of computer science, have been active participants in the organization and benefited from its programs and resources. They describe MORE as an essential place at Yale School of Medicine for connecting with other faculty who share their backgrounds and experiences. Now, they say, they hope to expand its reach.