Study Reveals Persistent Racial and Ethnic Disparities in Prevalence of Multiple Chronic Conditions
A Yale study found persistent racial and ethnic disparities in multimorbidity, which is defined as the presence of two or more concurrent chronic health conditions, in the United States over a 20-year period.
Yale researchers call for strategies to eliminate inequities in access to peripheral artery disease care among adults who share a Hispanic background
Adults who share a Hispanic background and who get hospitalized for symptoms of peripheral artery disease (PAD) are more likely to only receive care at later stages of their disease, and get their treatment through the emergency department instead of early stage disease care, elective care as compared with non-Hispanic white patients.
Breaking Stereotype: Brain Models Are Not One-Size-Fits-All
Using machine learning, scientists can create models to make predictions about the behavior and health of individuals.Yale researchers examined why these models tend to fail, why that happens, and what can be done about it.Source: YaleNews
To Break Through Bacteria’s Protective Shield, Target the Shield-maker
Yale researchers have now uncovered a key part of the process that generates an additional protective layer of the cell wall of bacteria, a finding that may help reveal vulnerabilities that could be targeted by new antibiotics.Source: YaleNews
Yale-developed Technology Restores Cell, Organ Function in Pigs After Death
Using a new technology they developed that delivers a specially designed cell-protective fluid to organs and tissues, the researchers restored blood circulation and other cellular functions in pigs a full hour after their deaths.Source: YaleNews
Two Heart Medications Tied to Greater Heart Attack Risk During Very Hot Weather
A new Yale study found that, among people suffering non-fatal heart attacks associated with hot weather, an outsize portion were taking beta-blockers or antiplatelet medication. The study doesn’t prove that these medications caused the heart attacks, nor that they make people more vulnerable to heart attack. Although it’s possible that they did increase the risk of heart attacks triggered by hot weather, it’s also possible that patients’ underlying heart disease explains both the prescriptions and the higher susceptibility to heart attack during hot weather.
A New Path for Treating Brain Cancer With a Yale-developed Compound
Yale researchers have developed a new class of molecules that target some of the deadliest brain cancers while sparing healthy tissue. The discovery combines innovative synthetic chemistry and cutting-edge mechanistic studies in molecular biology, and offers a potentially powerful new approach to treating drug-resistant glioma tumors.
Yale-developed Vaccine Offers Superior Protection Against Omicron Variants
The experimental vaccines use engineered lipid nanoparticles to deliver mRNA to cells with “instructions” to create spike proteins from mutating variants, which the virus uses to attach to and infect cells.Source: YaleNews
A Computational Solution for Bolstering Reliability of Epigenetic Clocks
Epigenetic clocks are powerful biomarkers based on DNA methylation that were developed to track aging in population studies, clinical trials, and personal health applications. Intended to measure biological age, they strongly predict age-related morbidity and mortality along with other aspects of health. Now, scientists from Yale School of Medicine, in collaboration with international research colleagues, have developed a new approach to make them substantially more reliable.
Vaccine Protection Against COVID-19 Short-lived, Booster Shots Important, New Study Says
Since COVID-19 vaccines first became available to protect against infection and severe illness, there has been much uncertainty about how long the protection lasts, and when it might be necessary for individuals to get an additional booster shot. Now, a team of scientists led by faculty at the Yale School of Public Health and the University of North Carolina at Charlotte has an answer: strong protection following vaccination is short-lived.
Scientists Zero in on Genetic Causes of Parkinson’s
In two new papers, scientists provide insight into the function of a protein called VPS13C, one of the molecular suspects that underlie Parkinson’s, a disease marked by uncontrollable movements including tremors, stiffness, and loss of balance.Source: YaleNews
Most Children With Obesity Aren’t Screened Properly for Related Conditions
Most children in the United States diagnosed with obesity do not receive recommended laboratory tests for co-occurring conditions such as diabetes and liver disease, a new Yale study finds. Many also receive potentially unnecessary tests, and both can be harmful to patients, the researchers say.Source: YaleNews
How Gut Microbes Can Evolve and Become Dangerous
Gut bacteria can evolve over time within the host, becoming more pathogenic by gaining the ability to migrate across the gut barrier and persist in organs outside of the intestine, thereby driving chronic inflammation and associated pathologies.Source: YaleNews
Using Particles That Are Smaller Than the Head of a Pin to Treat Cancer
Thanks in part to research begun more than a decade ago with funding from Women’s Health Research at Yale, Dr. W. Mark Saltzman is working with colleagues on a way to deploy effective cancer-fighting medication safely with the help of nanoparticles.
Yale researchers show how the liver can control the brain and behavior
A new Yale study found that the liver plays a major role in regulating feeding behavior in mice, a discovery that could have implications for people with eating disorders and metabolic diseases. The study, which was done in collaboration with colleagues in Germany, also adds to a growing body of evidence that shows the most advanced part of the brain, the cerebral cortex, is affected by the rest of the body, not just the other way around.Source: YaleNews