With Cellular Blueprint for Lungs, Yale Researchers Look Ahead to Organ Regeneration
Using sophisticated screening across animal species, researchers at Yale have created a cellular blueprint of the human lung that will make it easier to understand the design principles behind lung function and disease — and to bioengineer new lungs. The research, published Dec. 4 in Science Advances, represents a collaboration between two Yale labs — that of Naftali Kaminski, M.D., chief of pulmonary, critical care, and sleep medicine at Yale School of Medicine, and Laura Niklason, M.D., Ph.D., the Nicholas Greene Professor of anesthesiology and biomedical engineering and an expert in stimulating growth of new lung tissue from the body’s own cells for use in transplants.
New test could lead to personalized treatments for cystic fibrosis
Cystic fibrosis is a devastating disease caused by mutations in a specific gene, known as the CFTR gene. But not everyone with cystic fibrosis has the same symptoms or responds to drug treatments in the same way. In a new pilot study, researchers from the University of Cambridge and Yale University developed a novel, straightforward way to test multiple drugs on cells obtained from individual patients with cystic fibrosis, raising the possibility of highly personalized drug treatment.
Fighting the Cold Virus and Other Threats, Body Makes Trade-off, Says Study
A Yale research team has revealed how cells in different parts of the human airway vary in their response to the common cold virus. Their finding, published in Cell Reports, could help solve the mystery of why some people exposed to the cold virus get ill while others don’t, said the researchers.
Proposed legislation would subject e-cigarettes to age verification law
New legislation proposed June 5 by Congresswoman Rosa DeLauro, D-Conn., would require Internet and mail order sellers of electronic cigarettes to verify a person’s age and identity before they deliver their products to a buyer’s door.
Crosstalk between cells plays role in pulmonary hypertension
Pulmonary hypertension is a type of high blood pressure that affects blood vessels in the lungs. Once diagnosed, patients have limited treatment options, and many do not live beyond seven years. In a new study, scientists in the Yale Cardiovascular Research Center have gained new insight into the development of the disease that could lead to new therapies.
New Research Opens Door for Potential Treatment of Deadly Lung Disease
Chronic Obstructive Pulmonary Disease (COPD) is the fourth leading cause of death globally Every year, over 12 million U.S. adults are diagnosed with COPD, and 120,000 die from it. For people with the disease, the bacterium Haemophilus influenzae is particularly dangerous.
Early Screening for Lung Cancer? Many people are not aware you can be tested for the disease
Lung cancer is the second most common cancer in both men and women, and is by far the leading cause of cancer death. In 2017, the American Cancer Society estimates more than 200,000 new cases of lung cancer will be diagnosed in the United States, with more than 150,000 deaths. Lung cancer screening is now approved in the United States, and can help detect cancer early, when it is most curable. With November Lung Cancer Awareness Month, Lynn Tanoue, MD and Polly Sather, MSN, APRN, from the Lung Screening and Nodule Program at Yale Cancer Center, talk about lung cancer screening and why it can save lives.
Yale study: Chest physicians split on pros and cons of e-cigarettes
Benjamin Toll, PhD, Lecturer in the Yale Department of Psychiatry, is among the authors of a study published in the Journal of Smoking Cessation that surveyed chest physicians about their experiences with e-cigarette users and their opinion about the products.
Exploring the mysteries of sleep with Dr. Meir Kryger
We spend one-third of our lives in bed, yet little is known about the purpose of sleep, says Meir Kryger, M.D, For more than 40 years, Kryger has been working to answer some of the remaining questions about sleep through innovative research and clinical practice.
Hospital quality linked to readmission rates for COPD and other diseases
Nearly one in five patients admitted to hospitals in the United States are readmitted within 30 days, at a cost of $17 billion annually. To reduce readmission rates, the federal Centers for Medicare & Medicaid Services (CMS) tracks readmissions for certain conditions, including heart failure, pneumonia, and most recently, chronic obstructive pulmonary disorder (COPD), a disease of the lungs.
Q&A: New CPIRT director on lung infections, antibiotics, and climate change
This summer, the new Yale Center for Pulmonary Infection Research and Treatment (CPIRT) held its first meeting, with the goal of breathing fresh air into the science of lung infection. Conceived by associate professor Dr. Charles Dela Cruz as a cross-disciplinary hub for investigators, CPIRT brings together innovative minds from basic, translational, and clinical research areas across Yale. The center’s ultimate aim is to develop better treatments for both acute and chronic ailments — from pandemic flu to emphysema — that are affected by lung infections.
Cystic fibrosis patient improves health, inspires others through distance running
Liz Shuman Peri doesn't let cystic fibrosis stop her from living a full life. She became a long distance runner to improve her health and attitude. Yale Medicine physicians say it’s a smart strategy.Source: Yale Medicine
Precision Medicine: Custom Treatment From Your Genes
In 2001, we thought it was a remarkable accomplishment to sequence an entire human genome and do that once. Today, we're doing this thousands of times a day around the world. These lead to not just new diagnoses, but also can lead to new therapies that might not have been thought of previously.Source: WebMD
Pulmonary embolism treatment widely used, despite uncertain benefit
Despite being costly and of little proven benefit, a procedure for treating pulmonary embolism with blood clot filters is routinely used in older adults, Yale School of Medicine researchers and their colleagues found in a new study.
Research in the news: Yale-led study finds risk of pulmonary embolism from ultrasound
Ultrasound is the most common technique for detecting a widespread cardiovascular condition: blood clots in the leg, otherwise known as deep vein thrombosis (DVT). But there’s a little known — yet serious — risk to using ultrasound to diagnose DVT, say Yale researchers in a new study published this week by Seminars in Thrombosis and Hemostasis.