Gut check: Yale researchers describe role of bacteria in drug response
Yale researchers identified human gut microbes that metabolize over 150 therapeutic drugs, a finding that highlights the role bacteria play in determining how well individuals respond to medications, they report June 3 in the journal Nature.
A Zika Vaccine Could Virtually Eliminate Prenatal Infections
A Zika vaccine could have a substantial effect on mitigating and preventing future Zika virus outbreaks. Through a combination of direct protection and indirect reduction of transmissions, virtual elimination is achievable, even with imperfect vaccine efficacy and coverage, a new Yale School of Public Health study finds.
Study: Topical antibiotic triggers unexpected antiviral response
A Yale-led research team made a startling discovery while investigating the effect of bacteria on viral infections. When they applied a common topical antibiotic to mice before or shortly after infection with herpes and other viruses, they found that the antibiotic triggered an antiviral resistance in the animals, the researchers said.
Unpredictability the key to “rewiring” our fight against infection: In conversation with Professor John MacMicking
John MacMicking of the Systems Biology Institute talks about his work to integrate abstract and experimental science in an effort to “rewire” the host immune response to infection. Dr. MacMicking is an Investigator of the Howard Hughes Medical Institute (HHMI) and tenured Associate Professor of Microbial Pathogenesis and of Immunobiology at the School of Medicine.Source: Yale West Campus News
Yale scientist Nikhil S. Malvankar receives Hood Foundation Child Health Research Award
Nikhil Malvankar, assistant professor of Molecular Biophysics and Biochemistry at Yale’s Microbial Sciences Institute, has received a Charles H. Hood Foundation Child Health Research Award for his project The Role of Charge Interactions in Pseudomonas aeruginosa infections in Cystic Fibrosis. Malvankar is one of five recipients to receive an award.
Bacterial brawls mark life in the gut’s microbiome
Bacterially speaking, it gets very crowded in the human gut, with trillions of cells jostling for a position to carry out a host of specialized and often crucial tasks. A new Yale study, published the week of March 7 in the journal of the Proceedings of the National Academy of Sciences suggests these “friendly” bacteria aggressively stake out their territory, injecting lethal toxins into any other cells that dare bump into them.
Hinchcliff is New Director of Yale Scleroderma Program
Monique Hinchcliff, MD, MS, was named director of the Yale Scleroderma Program. Hinchcliff leads an established multidisciplinary team of expert physician-scientists with an interest and expertise in systemic sclerosis, also called scleroderma.