Nasal Vaccine May Aid Fight Against New Viral Variants
Akiko Iwasaki and her colleagues found that intranasal vaccination provided broad-based protection against heterologous respiratory viruses in mice, while so-called systemic immunization, which uses an injection to elicit body-wide protection, did not.Source: YaleNews
Improving the Diagnosis of Heart Disease in Women
Dr. Samit Shah is leading a team to demonstrate the effectiveness of validated, but not widely administered procedures for the many women who have reduced blood flow to the heart without blocked arteries or cholesterol build-up often associated with heart disease.
Virtual Reality Game Is an Effective Tool for Vaping Prevention Among Teens
The game prompts students to practice navigating peer pressure situations involving vaping. By encouraging teens to use their own voices in simulated situations, the researchers hoped they would become better prepared to face real-world scenarios.
Psychedelic Spurs Growth of Neural Connections Lost in Depression
In a new study, Yale researchers show that a single dose of psilocybin given to mice prompted an immediate and long-lasting increase in connections between neurons. The findings are published July 5 in the journal Neuron.Source: Yale News
Sex-specific Immune Response in COVID-19 Linked to Cellular Metabolism
Researchers studying COVID-19 patients have found a metabolic pathway that is highly correlated with immune responses only in male patients, a group known to be more likely to suffer severe cases and die of the disease, representing a potential target for therapeutic intervention.Source: Yale News
WHRY Funds Study on How CBD Affects the Brain
Women’s Health Research at Yale announced funding to investigate how the presumably non-intoxicating cannabis ingredient cannabidiol (CBD) affects the brain, and if it affects women and men differently. CBD use is growing in popularity exponentially, yet the safety and effectiveness of this non-regulated category of products are unknown.
WHRY Launches Studies on Endometrial Cancer, Addiction to Opioids, and Stroke
While continuing to focus on the impacts of COVID-19, the center has enlarged its research portfolio to include new projects on the prevention of endometrial cancer in a growing cohort of women at high risk, non-opioid pain management following a cesarean section for women with opioid use disorder who are in recovery, and sex differences in stroke.
New Imaging Tool Helps Researchers See Extent of Alzheimer’s Early Damage
New imaging technology allows scientists to see the widespread loss of brain synapses in early stages of Alzheimer’s disease, a finding that one day may aid in drug development, according to a new Yale University study.Source: Yale News
Deadlier Colon Cancer Develops Differently in Women and Men
WHRY-affiliated researchers have found that colon cancer tumor cells produce energy for growth differently in women and men, and that this difference is associated with a more aggressive form of tumor growth with a higher incidence in women.
Yale Launches Comprehensive DNA Sequencing Project, With Aim of Predicting, Preventing, and Treating Gene-related Diseases
Generations, a collaboration between Yale School of Medicine and Yale New Haven Health System, is one of the largest DNA sequencing projects of its kind in the United States.
Yale-developed Scorecard Promotes Better Clinical Trial Data Sharing
A tool developed by researchers at Yale, Stanford, and Bioethics International can promote greater sharing of clinical trial data by pharmaceutical companies. While nearly one-third of the companies that the researchers assessed met standards for sharing data, others could be more transparent to the benefit of science and the public, the researchers said.
Department of Neurology Receives Major Grant to Evaluate Blood Thinners and Stroke Prevention
Yale School of Medicine has received a 5-year, $20 million grant from the National Institute of Neurological Disorders and Stroke (NINDS) to administer a Phase III trial measuring the effectiveness of using a blood thinner to prevent new strokes in patients who suffered brain hemorrhages and have atrial fibrillation, or irregular heartbeat.
Chen and Team Win Award from 2019 NIDA $100K SUD Startup Challenge
Kevin Chen, MD, fellow, National Clinical Scholars Program, and his team recently won an award as part of the 2019 NIDA $100K SUD Startup Challenge. Sponsored by the National Institute on Drug Abuse, the award is given to 10 winners for their startup projects to improve the well-being of those with substance use disorders.
Implementation Science: Putting Important Discoveries to Their Best Use
Scientific innovations are created every day, but how do we ensure that they are used efficiently and reach the people who need them most? David Chambers, DPhil, deputy director for implementation science in the Division of Cancer Control & Population Sciences at the National Cancer Institute, tackled that question during his June 25 grand rounds lecture titled “Advancing the Science of Implementation in Cancer Control: An NCI Perspective."
Yale Cancer Center Partners in Fight to Help Eliminate HPV-related Cancers
Yale Cancer Center joins the Association of American Cancer Institutes (AACI) and its partner organizations to endorse a Call to Action for our nation to work together toward the elimination of human papillomavirus (HPV)-related cancers.
Yale Cancer Center scientists discover molecular key to how cancer spreads
Yale Cancer Center researchers have discovered how metastasis, the spread of cancer cells throughout the body, is triggered on the molecular level, and have developed a tool with the potential to detect those triggers in patients with certain cancers. The discovery could lead to new ways for treating cancer.
How the Brain Helps Us Make Good Decisions — and Bad Ones
A prevailing theory in neuroscience holds that people make decisions based on integrated global calculations that occur within the frontal cortex of the brain. However, Yale researchers have found that three distinct circuits connecting to different brain regions are involved in making good decisions, bad ones, and determining which of those past choices to store in memory, they report June 25 in the journal Neuron.