Multimodal Neuroimaging of Stress, Arousal, and Alcoholism Risk

Trial Purpose and Description

To examine chronic alcohol-related changes in primary and secondary predictors in AD patients during acute and protracted alcohol abstinence, and in AD patients relative to social drinkers.

Ages: 18 - 60 years

Gender: Both

Eligibility Criteria

Inclusion Criteria:

i)Male and females, aged 18-60 years;

ii)Good health as verified by screening examination;

iii)Able to read English and complete study evaluations; iv)Able to provide informed written and verbal consent;

v) AD sample must meet DSM-5 criteria for AUD as assessed using SCID-I and have positive alcohol urine toxicology screens on admission to study; while HC group must never have met criteria for AUD, with non-binging and nonhazardous alcohol intake levels( men: below15 drinks/week; women: less than 8 drinks/week); and with negative alcohol urine toxicology screens;

Exclusion Criteria:

(i)Meet current criteria for dependence on another psychoactive substance, excluding nicotine;

(ii)Current use of opiates or past history of opiate abuse/dependence;

(iii)Regular use of anticonvulsants, sedatives/hypnotics, prescription analgesics, other antihypertensives, anti-arrythmics, antiretroviral medications, tricyclic antidepressants, SSRI’s naltrexone, antabuse;

(iv)Psychotic or otherwise severely psychiatrically disabled (i.e., suicidal, homicidal, current mania);

(v)Significant underlying medical conditions such as a history of seizure disorder, cerebral, renal, thyroid or cardiac pathology which in the opinion of study physician would preclude subjects from fully cooperating or be of potential harm during the course of the study;

(vi)Any psychotic disorder or current Axis I psychiatric symptoms (excluding anxiety disorders) requiring specific attention, including need for psychiatric medications;

(vii)hypotensive individuals with sitting blood pressure below 90/50 mmHG;

(viii)Women who are pregnant, nursing or refuse to use a reliable form of birth control (as assessed by pregnancy tests during initial medical evaluation, and assessed every two weeks during the course of the study); and

(ix)those with metal in their body excluded from MRI due to safety.

National Institute on Alcohol Abuse and Alcoholism

Start Date: 12/01/2015

End Date: 06/30/2021

Last Updated: 06/22/2018

Study HIC#: 1501015225

Get Involved

For more information about this study, contact:
Rachel Hart
+1 888-978-7377

If you would prefer to contact a member of the Help us Discover team about this trial and other similar trials, please email or call 1-877-978-8348.

Trial Image


Rajita Sinha

Principal Investigator