Diagnosing and Targeting Mechanisms of Diuretic Resistance in Heart Failure

What is the purpose of this trial?

The overarching goal of this study is to create and validate pragmatic tools to rapidly detect and then define the mechanism of diuretic resistance, allowing individualized therapy for acute decompensated heart failure.

The scientific aims of this study are:

  1. to develop inexpensive and efficient tools to predict diuretic response in a reliable and timely manner,
  2. to understand the prevalence of therapeutically targetable mechanisms of diuretic resistance
using endogenous lithium clearance, a "gold standard" technique to query in
vivo proximal tubular/loop of Henle sodium handling,
  3. to develop
methodology to differentiate diuretic resistance mechanisms using common/inexpensive
laboratory tests
  4. to provide proof of concept that mechanistically tailored
diuretic therapy can improve natriuresis and

  5. to establish a biorepository of urine, blood, and DNA specimens for future study of mechanisms and the impact of diuretic resistance.

Participation Guidelines

Ages: 18 years and older

Gender: Both

National Heart, Lung, and Blood Institute

Start Date: 08/24/2015

End Date: 07/01/2025

Last Updated: 02/22/2018

Study HIC#: 1505015805

Get Involved

For more information about this study, contact:
Jennifer Tainsh

If you would prefer to contact a member of the Help us Discover team about this trial and other similar trials, please email helpusdiscover@yale.edu or call 1-877-978-8348.

Trial Image


Jeffrey Testani

Principal Investigator