Diseases of the Cardiovascular System

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2)

Volunteers
Health Professionals

What is the purpose of this trial?

Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will randomize patients in a 1:1 ratio to carotid stenting with embolic protection versus no stenting. Medical management will be uniform for all randomized treatment groups and will be centrally directed.

Trial with
Mayo Clinic Jacksonville Florida
Ages
35 years - 100 years
Gender
Both

Find out more about who can participate in this trial

Contact Information

For more information about this study, including how to volunteer, contact Juan Carmona

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You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact helpusdiscover@yale.edu, or call 877.978.8343 for more information.

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Principal Investigator

Carlos Mena-Hurtado, MD, FACC, FSCAI, FAHA
Associate Professor of Medicine (Cardiology); Director CME, Section of Cardiology, Internal Medicine; Co-Director Limb Preservation Program, Yale New Haven Health System; Honorary Clinical Reader in Centre, Clinical Pharmacology in the William Harvey Research Institute; Co-Director Vascular Outcomes Program, Internal Medicine; Primary Member, Yale Institutional Review Board; Consultant, Center For Devices and Radiological Health; Member, Yale School of Medicine Progress Committee; Medical Director Vascular Medicine - YNHH, Internal Medicine; Interventional Cardiology Item-Writing Task Force, Task Force

Sub-Investigators

Last Updated
01/07/2024
Study HIC
#1501015248