Mechanisms for restoration of hypoglycemia awareness

What is the purpose of this trial?

Determine the impact of frequent hypoglycemia and hypoglycemia unawareness on brain responses to visual food cues as well as brain functional connectivity in T1DM patients. Aim 2: Assess the impact of antecedent bouts of hypoglycemia on brain glucose transport/metabolism during hyperglycemia in T1DM Unaware, T1DM Aware as well as healthy controls using 1H, 13C magnetic resonance spectroscopy (MRS). Aim 3: Determine if reducing hypoglycemia and glycemic variability using closed loop insulin delivery reverses altered brain glucose transport/metabolism and functional connectivity in hypoglycemia unaware T1DM patients.

National Institute of Diabetes and Digestive & Kidney Diseases

Start Date: 11/07/2018

End Date: 04/30/2023

Last Updated: 11/19/2018

Study HIC#: 2000023189

Get Involved

For more information about this study, contact:
Mari-Lynet Knight
+1 203-737-4777

If you would prefer to contact a member of the Help us Discover team about this trial and other similar trials, please email or call 1-877-978-8348.

Trial Image


Janice Jin Hwang

Principal Investigator