Vitamin D as a Therapeutic Adjunct in the Stimulant Treatment of ADHD

What is the purpose of this trial?

Specific Aim 1: As part of a within-subject, two-days, study design, to determine whether acute calcitriol (vs. placebo) pre-treatment is associated with greater amphetamine (Amp)-induced dopamine (DA) release in the caudate, putamen, ventral striatum (VST), and substantia nigra / ventral tegmental area (SN/VTA) of healthy human subjects.

Specific Aim 2: To determine whether acute calcitriol (vs. placebo) pre-treatment is associated with better performance on a test of attention (e.g., the continuous Performance Task or CPT-AX), after treatment with amphetamine. Hypothesis: Investigators hypothesize that Subjects pre-treated with calcitriol will have faster reaction times/higher accuracy on the CPT-AX vs. subjects pre-treated with placebo, after treatment with amphetamine.


Participation Guidelines

Ages: 18 - 50 years

Gender: Both


Brain and Behavior Research Foundation

Start Date: 04/19/2017

End Date: 12/31/2021

Last Updated: 06/22/2018

Study HIC#: 2000020604

Get Involved

For more information about this study, contact:
Jessica Costeines
+1 203-520-6398
jessica.costeines@yale.edu

If you would prefer to contact a member of the Help us Discover team about this trial and other similar trials, please email helpusdiscover@yale.edu or call 1-877-978-8348.

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