Imaging Tobacco Smoking Withdrawal using [11C]PHNO

What is the purpose of this trial?

This research study is designed to look at the involvement of the dopamine systems in smoking, and the way people feel and think. This study will help us further examine brain chemistry and nicotine addiction. This study accepts both healthy non-smoker and healthy smoker subjects. Healthy non-smoker subjects will receive 1 PET scan with the radiotracer PHNO along with an amphetamine challenge and 1 mri . 

Healthy smoker subjects will be asked to quit smoking for up to 8 weeks and will receive up to 2 PET scans with the radiotracer PHNO along with 2 amphetamine challenges and 2 mris over the course of their abstinence. 


Participation Guidelines

Ages: 18 - 55 years

Gender: Both


National Institute on Drug Abuse

Start Date: 09/20/2017

End Date: 09/30/2022

Last Updated: 11/29/2018

Study HIC#: 2000021470

Get Involved

For more information about this study, contact:
Shannan Henry
+1 203-737-5278
shannan.henry@yale.edu

If you would prefer to contact a member of the Help us Discover team about this trial and other similar trials, please email helpusdiscover@yale.edu or call 1-877-978-8348.

Trial Image