What is the purpose of this trial?
This research study is designed to look at the involvement of the dopamine systems in smoking, and the way people feel and think. This study will help us further examine brain chemistry and nicotine addiction. This study accepts both healthy non-smoker and healthy smoker subjects. Healthy non-smoker subjects will receive 1 PET scan with the radiotracer PHNO along with an amphetamine challenge and 1 mri .
Healthy smoker subjects will be asked to quit smoking for up to 8 weeks and will receive up to 2 PET scans with the radiotracer PHNO along with 2 amphetamine challenges and 2 mris over the course of their abstinence.
Ages: 18 - 55 years
National Institute on Drug Abuse
Start Date: 09/20/2017
End Date: 09/30/2022
Last Updated: 11/29/2018
Study HIC#: 2000021470