Intravenous (IV) Nicotine Self Administration: Dose Ranging and Sex Differences in Smokers

What is the purpose of this trial?

The proposed study will examine the threshold for nicotine self-administration using four different nicotine doses in young adult male and female smokers with-or-without nicotine dependence (light and intermittent smokers or LITS).

Aim #1: To further characterize the reinforcing threshold and dose-response curve for IV nicotine self-administration in male and female smokers with or without nicotine dependence. The reinforcing effects of nicotine will be determined by the number of IV nicotine self-administrations.

Hypothesis 1a) female smokers, compared to males, will have a lower threshold and a steeper slope for nicotine reinforcement, indicating greater sensitivity to nicotine.

Hypothesis 1b) non-dependent smokers, compared to dependent smokers, will have a lower threshold and a steeper slope for nicotine reinforcement.

Aim#2: To further characterize the threshold and dose-response curve for the subjective-rewarding effects of self-administered IV nicotine in male and female smokers with or without nicotine dependence. The subjective-rewarding effects of nicotine will be determined by the "good effects" and "drug liking" items of the Drug Effects Questionnaire.

Hypothesis 2a) female smokers, compared to males, will have a lower threshold and a steeper slope for the subjective-rewarding effects of nicotine.

Hypothesis 2b) non-dependent smokers, compared to dependent smokers, will have a lower threshold and a steeper slope for the subjective-rewarding effects of nicotine, indicating greater sensitivity to nicotine.


Participation Guidelines

Ages: 18 - 50 years

Gender: Both


National Institute on Drug Abuse

Start Date: 04/07/2011

End Date: 10/31/2015

Last Updated: 06/22/2018

Study HIC#: 1010007514

Get Involved

For more information about this study, contact:
Stacy Minnix
+1 203-937-4805
stacy.minnix@yale.edu

If you would prefer to contact a member of the Help us Discover team about this trial and other similar trials, please email helpusdiscover@yale.edu or call 1-877-978-8348.

Trial Image

Investigators

Mehmet Sofuoglu

Principal Investigator

Sub-Investigators