Impact of Hypoglycemia on Brain Ketone and Neurotransmitter Metabolism in Type 1 DM

Trial Purpose and Description

To determine the long-term effect of severe antecedent hypoglycemia in T1DM pateints on brain energy subtrate metabolism, in particular ketone body metabolism

Ages: 18 years and younger

Gender: Both

Eligibility Criteria

Inclusion criteria:

Group 1: 

  • Type 1 diabetes of > 5 years 
  • C-peptide negative 
  • Age 18-60 years 
  • On intensive insulin therapy 
  • HbA1c <7.5% 

Group 2: 

  • Non-diabetic 
  • Age 18-65 years

Exclusion criteria:

  • Pregnancy
  • Significant baseline anemia (hemoglobin <11.0 or hematocrit <33%)
  • A history of liver cirrhosis or porto-caval shunt surgery 
  • Any contraindications for MRI scanning, including presence of metallic implants or claustrophobia 
  • Vegetarian diet
  • Heavy exercise on a regular basis (i.e. marathon runners)
  • Subjects with a history of anxiety/panic attacks 

National Institute of Diabetes and Digestive & Kidney Diseases

Start Date: 09/29/2012

End Date: 09/29/2017

Last Updated: 02/22/2018

Study HIC#: 1208010648

Get Involved

For more information about this study, contact:
Brenda Dombkowski
+1 203-785-3925

If you would prefer to contact a member of the Help us Discover team about this trial and other similar trials, please email or call 1-877-978-8348.

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