Trial Purpose and Description
The Specific Aims for this pilot study are: 1. To determine the feasibility of a study to quantify intracerebral levels of GSH as measured by 1H MRS at 4 Tesla in young and old individuals; 2. To begin defining the relationship between peripheral markers of metabolic status and intracerebral GSH; 3. To explore how aging alters the relationships between intracerebral GSH levels, human functional brain connectivity, and neurocognitive performance.
Ages: 18 years and younger
Age 18-35 or age 65-85 years.
Diabetes, kidney, or liver disease.
History of major heart disease.
History of stroke or other neurologic and psychiatric diseases.
Inability to enter MRI due to claustrophobia or metal in the body
For women: pregnancy, seeking pregnancy, or breastfeeding
Yale Pepper Center
Start Date: 10/26/2017
End Date: 05/31/2020
Last Updated: 02/22/2018
Study HIC#: 2000021046