A phase II study of combination immunotherapy with ipilimumab and nivolumab in patients with advanced non-small cell lung cancer resistant to anti-PD-1-axis therapy

What is the purpose of this trial?

The drugs being combined in this study are nivolumab (Opdivo TM) and ipilimumab (Yervoy). You have already received nivolumab (Opdivo TM), or another drug that blocks the PD-1 pathway (e.g. pembrolizumab, Keytruda; atezolizumab, Tecentriq). When effective, PD-1 blockers such as these may release brakes on your immune system present in the tumor, allowing it to attack and control your cancer. It is thought that one reason why patients might not respond to PD-1 blockers is because not enough immune cells (called T cells) have made it into the tumor, where brakes are in place. The medication ipilimumab blocks the cytotoxic T-lymphocyte antigen (CTLA-4) pathway which may help bring these kinds of immune cells into the tumor. Furthermore, ipilimumab may help release other brakes on the immune system present in the tumor. The combination of nivolumab and ipilimumab is currently approved by the United States Food and Drug Administration (FDA) for the treatment of metastatic melanoma, and is more effective against melanoma than either medication alone. Early results of trials of this combination in your kind of cancer have been promising and reasonably safe, but it is not known what effects this combination will have in patients who have already received PD-1 blockers with subsequent tumor growth. This study will provide us with more information about whether this combination is effective in your kind of tumor.

Yale University

Start Date: 06/29/2017

End Date: 11/01/2019

Last Updated: 03/07/2019

Study HIC#: 2000020343

Get Involved

For more information about this study, contact:
Kira Pavlik
+1 203-785-6540

If you would prefer to contact a member of the Help us Discover team about this trial and other similar trials, please email helpusdiscover@yale.edu or call 1-877-978-8348.

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